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anti-ACOX1 antibody :: Rabbit anti-Human, Mouse ACOX1 Polyclonal Antibody

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Catalog # MBS9403251
Unit / Price
  0.1 mL  /  $255 +1 FREE 8GB USB
Product Name

ACOX1, Polyclonal Antibody

Popular Item
Also Known As

ACOX1 Antibody

Product Synonym Names
ACOX; SCOX; PALMCOX
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
622
OMIM
264470
3D Structure
ModBase 3D Structure for Q15067
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Specificity
The antibody detects endogenous levels of total ACOX1 protein.
Purity/Purification
Antigen affinity purification.
Form/Format
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Concentration
0.8 mg/ml (lot specific)
Immunogen Type
Recombinant Protein
Immunogen Description
Fusion protein corresponding to residues near the C terminal of human Acyl-CoA oxidase 1, palmitoyl
Target Name
ACOX1
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-ACOX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ACOX1 antibody
The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified.
Product Categories/Family for anti-ACOX1 antibody
Applications Tested/Suitable for anti-ACOX1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ACOX1 antibody
Western blotting: 1:200-1:1000
Immunohistochemistry: 1:15-1:50

Testing Data of anti-ACOX1 antibody
Gel: 8%SDS-PAGE Lysates (from left to right): Mouse stomach, liver and kidney tissue Amount of lysate: 40ug per lane Primary antibody: 1/350 dilution Secondary antibody dilution: 1/8000 Exposure time: 1 minute
anti-ACOX1 antibody Testing Data image
Immunohistochemistry (IHC) of anti-ACOX1 antibody
Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue using at dilution 1/20.
anti-ACOX1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for ACOX1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
74kd
NCBI Official Full Name
peroxisomal acyl-coenzyme A oxidase 1 isoform c
NCBI Official Synonym Full Names
acyl-CoA oxidase 1, palmitoyl
NCBI Official Symbol
ACOX1  [Similar Products]
NCBI Official Synonym Symbols
ACOX; SCOX; PALMCOX
  [Similar Products]
NCBI Protein Information
peroxisomal acyl-coenzyme A oxidase 1
UniProt Protein Name
Peroxisomal acyl-coenzyme A oxidase 1
UniProt Synonym Protein Names
Palmitoyl-CoA oxidase; Straight-chain acyl-CoA oxidase; SCOX
UniProt Gene Name
ACOX1  [Similar Products]
UniProt Synonym Gene Names
ACOX; AOX; SCOX  [Similar Products]
UniProt Entry Name
ACOX1_HUMAN
NCBI Summary for ACOX1
The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for ACOX1
ACOX1: Catalyzes the desaturation of acyl-CoAs to 2-trans- enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy- palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl- CoA. Defects in ACOX1 are the cause of adrenoleukodystrophy pseudoneonatal (Pseudo-NALD); also known as peroxisomal acyl-CoA oxidase deficiency. Pseudo-NALD is a peroxisomal single-enzyme disorder. Clinical features include mental retardation, leukodystrophy, seizures, mild hepatomegaly, hearing deficit. Pseudo-NALD is characterized by increased plasma levels of very-long chain fatty cids, due to decreased or absent peroxisome acyl-CoA oxidase activity. Peroxisomes are intact and functioning. Belongs to the acyl-CoA oxidase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Lipid Metabolism - alpha-linolenic acid; EC 1.3.3.6; Lipid Metabolism - unsaturated fatty acid biosynthesis; Lipid Metabolism - fatty acid

Chromosomal Location of Human Ortholog: 17q25.1

Cellular Component: nucleoplasm; peroxisomal membrane; peroxisomal matrix; membrane; mitochondrion; intracellular membrane-bound organelle; plasma membrane; nucleolus; peroxisome; nucleus

Molecular Function: palmitoyl-CoA oxidase activity; acyl-CoA dehydrogenase activity; acyl-CoA oxidase activity; FAD binding; protein N-terminus binding; fatty acid binding; receptor binding; PDZ domain binding

Biological Process: peroxisome fission; generation of precursor metabolites and energy; fatty acid beta-oxidation using acyl-CoA oxidase; very-long-chain fatty acid metabolic process; unsaturated fatty acid metabolic process; lipid homeostasis; spermatogenesis; fatty acid oxidation; lipid metabolic process; cellular lipid metabolic process; prostaglandin metabolic process

Disease: Peroxisomal Acyl-coa Oxidase Deficiency
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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