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anti-ACVR1B antibody :: Rabbit anti-Human, Mouse ACVR1B / ALK4 Polyclonal Antibody

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Catalog # MBS242161
Unit / Price
  0.05 mg  /  $530 +1 FREE 8GB USB
Product Name

ACVR1B / ALK4, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human ACVR1B / ALK4

Product Synonym Names
Anti-ACVR1B / ALK4 Antibody (C-Terminus) IHC-plus; ACVR1B; ACTR-IB; ACTRIB; ALK4; Activin receptor type IB; Activin A Receptor Type IB; Activin A receptor; type IB; Activin receptor-like kinase 4; ACVRLK4; ALK-4; Activin receptor type-1B; SKR2-2; SKR2; Human ACVR1B; ALK4
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P36896
Species Reactivity
Human, Mouse
Immunoaffinity Purified
PBS, 0.02% sodium azide
1 mg/ml (lot specific)
Target Species
Immunogen Description
A 14 amino acid peptide near the carboxy terminus of human ACVR1B.
Immunogen Type
Synthetic peptide
ACVR1B / ALK4 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human ACVR1B.
Antigen Modification
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Other Notes
Small volumes of anti-ACVR1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ACVR1B antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-ACVR1B antibody
IHC-P (5 ug/ml), WB (1 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-ACVR1B antibody
Anti-ACVR1 antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-ACVR1B antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-ACVR1B antibody
Western blot of ACVR1B in human kidney tissue lysate with ACVR1B antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.
anti-ACVR1B antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ACVR1B. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
51,725 Da
NCBI Official Full Name
activin receptor type-1B isoform a
NCBI Official Synonym Full Names
activin A receptor, type IB
NCBI Official Symbol
ACVR1B  [Similar Products]
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
activin receptor type-1B; activin receptor-like kinase 4; activin A receptor, type II-like kinase 4; serine/threonine-protein kinase receptor R2
UniProt Protein Name
Activin receptor type-1B
UniProt Synonym Protein Names
Activin receptor type IB; ACTR-IB; Activin receptor-like kinase 4; ALK-4; Serine/threonine-protein kinase receptor R2; SKR2
Protein Family
UniProt Gene Name
ACVR1B  [Similar Products]
UniProt Synonym Gene Names
ACVRLK4; ALK4; ACTR-IB; ALK-4; SKR2  [Similar Products]
UniProt Entry Name
NCBI Summary for ACVR1B
This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]
UniProt Comments for ACVR1B
ALK4: Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine- threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C- terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2. ACVRIB is abundantly expressed in systemic sclerosis patient fibroblasts and production of collagen is also induced by activin-A/INHBA. This suggests that the activin/ACRV1B signaling mechanism is involved in systemic sclerosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (receptor); EC; Protein kinase, TKL; Membrane protein, integral; TKL group; STKR family; Type1 subfamily

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: cell surface; integral to plasma membrane; plasma membrane; activin receptor complex; receptor complex

Molecular Function: activin receptor activity; metal ion binding; transmembrane receptor protein serine/threonine kinase activity; transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; activin receptor activity, type I; ubiquitin protein ligase binding; growth factor binding; activin binding; SMAD binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: development of primary female sexual characteristics; central nervous system development; in utero embryonic development; protein amino acid autophosphorylation; positive regulation of erythrocyte differentiation; peptidyl-threonine phosphorylation; activin receptor signaling pathway; signal transduction; protein amino acid phosphorylation; positive regulation of activin receptor signaling pathway; regulation of transcription, DNA-dependent; hair follicle development; transmembrane receptor protein serine/threonine kinase signaling pathway; positive regulation of transcription from RNA polymerase II promoter; negative regulation of cell growth; G1/S transition of mitotic cell cycle
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