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anti-AKR7A2 antibody :: Rabbit anti-Human, Mouse AKR7A2 Polyclonal Antibody

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Catalog # MBS7043862
Unit / Price
  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

AKR7A2, Polyclonal Antibody

Popular Item
Also Known As

AKR7A2 Antibody

Product Synonym Names
Aflatoxin B1 aldehyde reductase member 2; AFB1 aldehyde reductase 1; AFB1-AR 1; Aldoketoreductase 7; Succinic semialdehyde reductase; SSA reductase; AKR7A2; AFAR; AFAR1; AKR7
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
359
OMIM
603418
3D Structure
ModBase 3D Structure for O43488
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
Antigen Affinity Purified
Form/Format
Liquid
Species
Human
Immunogen
Recombinant human Aflatoxin B1 aldehyde reductase member 2 protein (C-260AA)
Conjugate
Non-conjugated
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-27765 / sc-27766 / sc-32944
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-AKR7A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AKR7A2 antibody
Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
Applications Tested/Suitable for anti-AKR7A2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western Blot (WB) of anti-AKR7A2 antibody
Western blot
All lanes: AKR7A2 antibody at 0.88 ug/ml
Lane 1: Mouse small intestine tissue
Lane 2: Mouse liver tissue
Lane 3: Mouse gonadal tissue
Lane 4: A431 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 40 kDa
Observed band size: 40 kDa

anti-AKR7A2 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-AKR7A2 antibody
Immunohistochemistry of paraffin-embedded human liver tissue using MBS7043862 at dilution 1:100
anti-AKR7A2 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-AKR7A2 antibody
Immunohistochemistry of paraffin-embedded human liver cancer using MBS7043862 at dilution 1:100
anti-AKR7A2 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for AKR7A2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,589 Da
NCBI Official Full Name
aflatoxin B1 aldehyde reductase member 2 isoform 1
NCBI Official Synonym Full Names
aldo-keto reductase family 7 member A2
NCBI Official Symbol
AKR7A2  [Similar Products]
NCBI Official Synonym Symbols
AFAR; AKR7; AFAR1; AFB1-AR1
  [Similar Products]
NCBI Protein Information
aflatoxin B1 aldehyde reductase member 2
UniProt Protein Name
Aflatoxin B1 aldehyde reductase member 2
UniProt Synonym Protein Names
AFB1 aldehyde reductase 1; AFB1-AR 1; Aldoketoreductase 7; Succinic semialdehyde reductase; SSA reductase
UniProt Gene Name
AKR7A2  [Similar Products]
UniProt Synonym Gene Names
AFAR; AFAR1; AKR7; AFB1-AR 1; SSA reductase  [Similar Products]
UniProt Entry Name
ARK72_HUMAN
NCBI Summary for AKR7A2
The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
UniProt Comments for AKR7A2
AKR7A2: Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2- nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.

Protein type: Oxidoreductase; EC 1.1.1.n11

Chromosomal Location of Human Ortholog: 1p36.13

Cellular Component: cytosol

Molecular Function: aldehyde reductase activity; aldo-keto reductase activity; electron carrier activity; phenanthrene-9,10-epoxide hydrolase activity

Biological Process: aldehyde metabolic process; carbohydrate metabolic process; xenobiotic metabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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