NP_001191760.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
anoctamin-10 isoform 2
NCBI Official Synonym Full Names
anoctamin 10
NCBI Protein Information
anoctamin-10
UniProt Protein Name
Anoctamin-10
UniProt Synonym Protein Names
Transmembrane protein 16K
UniProt Synonym Gene Names
UniProt Entry Name
ANO10_HUMAN
NCBI Summary for ANO10
The transmembrane protein encoded by this gene is a member of a family of calcium-activated chloride channels. Defects in this gene may be a cause of autosomal recessive spinocerebellar ataxia-10. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
UniProt Comments for ANO10
ANO10: May act as a calcium-activated chloride channel. Defects in ANO10 are the cause of spinocerebellar ataxia autosomal recessive type 10 (SCAR10). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR10 is characterized by onset in the teenage or young adult years of gait and limb ataxia, dysarthria, and nystagmus associated with marked cerebellar atrophy on brain imaging. Belongs to the anoctamin family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel
Chromosomal Location of Human Ortholog: 3p22.1
Cellular Component: membrane; plasma membrane; integral to membrane; intracellular
Molecular Function: intracellular calcium activated chloride channel activity; calcium activated cation channel activity
Biological Process: chloride transport; transmembrane transport; cation transport
Disease: Spinocerebellar Ataxia, Autosomal Recessive 10
Product References and Citations for anti-ANO10 antibody
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Schreiber R.,et al.J. Biol. Chem. 285:7838-7845(2010).
Duran C.,et al.Acta Pharmacol. Sin. 32:685-692(2011).
Research Articles on ANO10
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-ANO10 antibody
Pathways associated with anti-ANO10 antibody
Diseases associated with anti-ANO10 antibody
Organs/Tissues associated with anti-ANO10 antibody
|