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anti-ANPEP antibody :: Rabbit anti-Human, Mouse ANPEP Polyclonal Antibody

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Catalog # MBS7051737
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

ANPEP, Polyclonal Antibody

Popular Item
Also Known As

ANPEP Antibody

Product Synonym Names
Aminopeptidase N; AP-N; hAPN; Alanyl aminopeptidase; Aminopeptidase M; AP-M; Microsomal aminopeptidase; Myeloid plasma membrane glycoprotein CD13; gp150; CD13; ANPEP; APN; CD13; PEPN
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
967
OMIM
X13276 mRNA
3D Structure
ModBase 3D Structure for P15144
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Immunogen
Recombinant Human Aminopeptidase N protein (34-219AA)
Conjugation
Non-conjugated
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-ANPEP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ANPEP antibody
Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.
Applications Tested/Suitable for anti-ANPEP antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-ANPEP antibody
WB: 1:500-1:5000
IHC: 1:20-1:200
IF: 1:50-1:200

Western Blot (WB) of anti-ANPEP antibody
Western Blot
Positive WB detected in: Mouse kidney tissue
All lanes: ANPEP antibody at 3.4ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 110 KDa
Observed band size: 110 KDa

anti-ANPEP antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-ANPEP antibody
Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7051737 at dilution of 1:100
anti-ANPEP antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-ANPEP antibody
Immunohistochemistry of paraffin-embedded human liver tissue using MBS7051737 at dilution of 1:100
anti-ANPEP antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-ANPEP antibody
Immunofluorescent analysis of HepG2 cells using MBS7051737 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-ANPEP antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for ANPEP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
109,540 Da
NCBI Official Full Name
aminopeptidase N
NCBI Official Synonym Full Names
alanyl aminopeptidase, membrane
NCBI Official Symbol
ANPEP  [Similar Products]
NCBI Official Synonym Symbols
APN; CD13; LAP1; P150; PEPN; GP150
  [Similar Products]
NCBI Protein Information
aminopeptidase N
UniProt Protein Name
Aminopeptidase N
UniProt Synonym Protein Names
Alanyl aminopeptidase; Aminopeptidase M; AP-M; Microsomal aminopeptidase; Myeloid plasma membrane glycoprotein CD13; gp150; CD_antigen: CD13
Protein Family
UniProt Gene Name
ANPEP  [Similar Products]
UniProt Synonym Gene Names
APN; CD13; PEPN; AP-N; hAPN; AP-M  [Similar Products]
NCBI Summary for ANPEP
Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq, Jul 2008]
UniProt Comments for ANPEP
CD13: Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types including small intestinal and tubular epithelial cells, macrophages, granulocytes and synaptic membranes from the CNS. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection. Belongs to the peptidase M1 family.

Protein type: EC 3.4.11.2; Membrane protein, integral; Other Amino Acids Metabolism - glutathione; Protease; Receptor, misc.

Chromosomal Location of Human Ortholog: 15q26.1

Cellular Component: ER-Golgi intermediate compartment; extracellular space; integral to plasma membrane; lysosomal membrane

Molecular Function: aminopeptidase activity; metallopeptidase activity; peptide binding; receptor activity; zinc ion binding

Biological Process: peptide catabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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