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anti-BAF170 antibody :: Rabbit anti-Human, Mouse BAF170 Polyclonal Antibody

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Catalog # MBS9401447
Unit / Price
  0.05 mL  /  $200 +1 FREE 8GB USB
  0.1 mL  /  $255 +1 FREE 8GB USB
Product Name

BAF170, Polyclonal Antibody

Popular Item
Also Known As

BAF170 Polyclonal Antibody

Product Synonym Names
SMARCC2; BAF170; SWI/SNF complex subunit SMARCC2; BRG1-associated factor 170; BAF170; SWI/SNF complex 170 kDa subunit; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
1152
OMIM
601734
3D Structure
ModBase 3D Structure for Q8TAQ2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Specificity
BAF170 Polyclonal Antibody detects endogenous levels of BAF170 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration
1 mg/ml (lot specific)
SDS-PAGE MW
160 kd
Immunogen Type
peptide
Immunogen Description
Synthesized peptide derived from the Internal region of human BAF170.
Target Name
BAF170
Preparation and Storage
Store at -20°C/1 year
Other Notes
Small volumes of anti-BAF170 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-BAF170 antibody
Applications Tested/Suitable for anti-BAF170 antibody
Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-BAF170 antibody
Western Blot: 1:500 - 1:2000
Immunofluorescence: 1:200 - 1:1000
ELISA: 1:10000
Not yet tested in other applications.

Western Blot (WB) of anti-BAF170 antibody
Western Blot analysis of COLO205 cells using BAF170 Polyclonal Antibody
anti-BAF170 antibody Western Blot (WB) (WB) image
Western Blot (WB) of anti-BAF170 antibody
Western Blot analysis of 293T AD293 22RV1 HELA HepG2 cells using BAF170 Polyclonal Antibody
anti-BAF170 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for BAF170. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
SWI/SNF complex subunit SMARCC2 isoform c
NCBI Official Synonym Full Names
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
NCBI Official Symbol
SMARCC2  [Similar Products]
NCBI Official Synonym Symbols
Rsc8; BAF170; CRACC2
  [Similar Products]
NCBI Protein Information
SWI/SNF complex subunit SMARCC2
UniProt Protein Name
SWI/SNF complex subunit SMARCC2
UniProt Synonym Protein Names
BRG1-associated factor 170; BAF170; SWI/SNF complex 170 kDa subunit; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2
UniProt Gene Name
SMARCC2  [Similar Products]
UniProt Synonym Gene Names
BAF170; BAF170  [Similar Products]
UniProt Entry Name
SMRC2_HUMAN
NCBI Summary for BAF170
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for BAF170
SMARCC2: a core component of the BAF (SWI/SNF) complex. This family of complexes remodels chromatin structures, enabling transcription factors to gain access to DNA. They play important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling is due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors- specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain BAF53A and PHF10, are exchanged for homologous alternative BAF53B and BAF45B or BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand- bound VDR-mediated transrepression of the CYP27B1 gene. Component of 6 multiprotein chromatin-remodeling complexes: Swi/Snf-A (BAF), Swi/Snf-B (PBAF), Brm, Brg1(I), WINAC and Brg1(II). Each of the five complexes contains a catalytic subunit (either SMARCA4 or SMARCA2), and at least SMARCE1, BAF53A or BAF53B, SMARCC2 and SMARCB1. Other subunits specific to each of the complexes may also be present. Component of the BAF (hSWI/SNF) complex, which includes at least actin (ACTB), ARID1A, ARID1B, SMARCA2, SMARCA4, BAF53A, BAF53B, SMARCE1 SMARCC1, SMARCC2, SMARCB1, and one or more of SMARCD1, SMARCD2, or SMARCD3. In muscle cells, the BAF complex also contains DPF3. May also interact with the SIN3A histone deacetylase transcription repressor complex in conjunction with SMARCA2 and SMARCA4. The minimal complex composed of SMARCC1 and SMARCA4 seems to be able to associate with cyclin such as CCNE1 or transcription factors such as KLF1 or GATA1. Ubiquitously expressed. Belongs to the SMARCC family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor; DNA-binding

Chromosomal Location of Human Ortholog: 12q13.2

Cellular Component: nucleoplasm; SWI/SNF complex; protein complex; transcriptional repressor complex; nuclear chromatin

Molecular Function: protein binding; nucleosomal DNA binding; transcription coactivator activity

Biological Process: regulation of transcription from RNA polymerase II promoter; chromatin remodeling; establishment and/or maintenance of chromatin architecture; nucleosome disassembly; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment; ATP-dependent chromatin remodeling; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
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