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anti-BAI1 antibody :: Rabbit anti-Human, mouse BAI1 Polyclonal Antibody

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Catalog # MBS9213488
Unit / Price
  0.08 mL  /  $150 +1 FREE 8GB USB
  0.4 mL  /  $340 +1 FREE 8GB USB
Product Name

BAI1, Polyclonal Antibody

Popular Item
Also Known As

BAI1 Antibody (C-term)

Product Synonym Names
Brain-specific angiogenesis inhibitor 1; BAI1
Antibody/Peptide Pairs
BAI1 peptide (MBS9227612) is used for blocking the activity of BAI1 antibody (MBS9213488)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
1537-1567
Immunogen Sequence Length
1,584
OMIM
602682
3D Structure
ModBase 3D Structure for O14514
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human, mouse
Specificity
This BAI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1537-1567 amino acids from the C-terminal region of human BAI1.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.32 (lot specific)
Antigen Type
Synthetic Peptide
Cellular Location
Cell membrane; Multi-pass membrane protein Note=Likely to be concentrated at cell-cell adhesion sites
Tissue Location
Specifically expressed in brain. Reduced or no expression is observed in some glioblastoma cell lines and cancer tissues. No expression in astrocytes
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-BAI1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BAI1 antibody
Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas.

Function: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. May function in cell adhesion and signal transduction in the brain.
Applications Tested/Suitable for anti-BAI1 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry-Paraffin (IHC-P), Flow Cytometry (FC/FACS)
Application Notes for anti-BAI1 antibody
WB~~1:1000
IHC-P~~1:10~50
FC~~1:10~50

Western Blot (WB) of anti-BAI1 antibody
BAI1 Antibody (Q1552) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the BAI1 antibody detected the BAI1 protein (arrow).
anti-BAI1 antibody Western Blot (WB) (WB) image
Western Blot (WB) of anti-BAI1 antibody
BAI1 Antibody (Q1552) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the BAI1 antibody detected the BAI1 protein (arrow).
anti-BAI1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-BAI1 antibody
BAI1 antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of BAI1 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
anti-BAI1 antibody Immunohistochemistry (IHC) (IHC) image
Flow Cytometry (FC/FACS) of anti-BAI1 antibody
BAI1 Antibody (C-term) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-BAI1 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
NCBI/Uniprot data below describe general gene information for BAI1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
173501
NCBI Official Full Name
brain-specific angiogenesis inhibitor 1
NCBI Official Synonym Full Names
adhesion G protein-coupled receptor B1
NCBI Official Symbol
ADGRB1  [Similar Products]
NCBI Official Synonym Symbols
BAI1; GDAIF
  [Similar Products]
NCBI Protein Information
brain-specific angiogenesis inhibitor 1
UniProt Protein Name
Brain-specific angiogenesis inhibitor 1
Protein Family
UniProt Gene Name
UniProt Entry Name
BAI1_HUMAN
NCBI Summary for BAI1
Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008]
UniProt Comments for BAI1
BAI1: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. May function in cell adhesion and signal transduction in the brain. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

Protein type: Membrane protein, integral; GPCR, family 2; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 8q24.3

Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane; intercellular junction

Molecular Function: G-protein coupled receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of cell proliferation; negative regulation of angiogenesis; axonogenesis; signal transduction; cell adhesion; peripheral nervous system development
Product References and Citations for anti-BAI1 antibody
Kaur, B., et al., Am. J. Pathol. 162(1):19-27 (2003). Mori, K., et al., Neurosci. Res. 43(1):69-74 (2002). Duda, D.G., et al., Br. J. Cancer 86(3):490-496 (2002). Shiratsuchi, T., et al., Biochem. Biophys. Res. Commun. 247(3):597-604 (1998). Fukushima, Y., et al., Int. J. Oncol. 13(5):967-970 (1998).

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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