NP_001194.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
60,582 Da
NCBI Official Full Name
bone morphogenetic protein receptor type-1B isoform b
NCBI Official Synonym Full Names
bone morphogenetic protein receptor type 1B
NCBI Official Synonym Symbols
ALK6; AMDD; BDA2; ALK-6; BDA1D; CDw293 [Similar Products]
NCBI Protein Information
bone morphogenetic protein receptor type-1B
UniProt Protein Name
Bone morphogenetic protein receptor type-1B
UniProt Synonym Protein Names
CD_antigen: CDw293
UniProt Synonym Gene Names
UniProt Entry Name
BMR1B_HUMAN
NCBI Summary for BMPR1B
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
UniProt Comments for BMPR1B
BMPR1B: a kinase of the STKR family. A type I cell-surface receptor for bone morphogenetic protein. Expressed at ighest level in the prostate. May be upregulated by androgen stimulation in cells which expresses the androgen receptor.
Protein type: Protein kinase, TKL; EC 2.7.11.30; Protein kinase, Ser/Thr (receptor); Kinase, protein; Membrane protein, integral; TKL group; STKR family; Type1 subfamily
Chromosomal Location of Human Ortholog: 4q22-q24
Cellular Component: integral to plasma membrane; plasma membrane; receptor complex
Molecular Function: ATP binding; glycoprotein binding; protein binding; protein serine/threonine kinase activity; SMAD binding; transmembrane receptor protein serine/threonine kinase activity
Biological Process: BMP signaling pathway; chondrocyte development; eye development; limb morphogenesis; ovarian cumulus expansion; ovulation cycle; positive regulation of bone mineralization; positive regulation of cell differentiation; positive regulation of chondrocyte differentiation; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; proteoglycan biosynthetic process; skeletal development
Disease: Brachydactyly, Type A2; Chondrodysplasia, Acromesomelic, With Genital Anomalies
Research Articles on BMPR1B
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Products associated with anti-BMPR1B antibody
Pathways associated with anti-BMPR1B antibody
Diseases associated with anti-BMPR1B antibody
Organs/Tissues associated with anti-BMPR1B antibody
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