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anti-C8B antibody :: Rabbit anti-Human, Mouse C8B Polyclonal Antibody

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Catalog # MBS7044419
Unit / Price
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  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

C8B, Polyclonal Antibody

Popular Item
Full Product Name

C8B Antibody

Product Synonym Names
Complement component C8 beta chain; Complement component 8 subunit beta; C8B
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
120960
3D Structure
ModBase 3D Structure for P07358
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
Antigen Affinity Purified
Form/Format
Liquid
Species
Human
Immunogen
Recombinant human Complement component C8 beta chain protein (55-350AA)
Conjugate
Non-conjugated
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-130999
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-C8B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-C8B antibody
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
Applications Tested/Suitable for anti-C8B antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western Blot (WB) of anti-C8B antibody
Western blot
All lanes: C8B antibody at 1.28 ug/ml
Lane 1: Hela whole cell lysate
Lane 2: Jurkat whole cell lysate
Lane 3: HepG-2 whole cell lysate
Lane 4: Raji whole cell lysate
Lane 5: Mouse liver tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 67 kDa
Observed band size: 67,50 kDa

anti-C8B antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-C8B antibody
Immunohistochemistry of paraffin-embedded human liver cancer using MBS7044419 at dilution of 1:100
anti-C8B antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-C8B antibody
Immunohistochemistry of paraffin-embedded human pancreatic cancer using MBS7044419 at dilution of 1:100
anti-C8B antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for C8B. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
67,047 Da
NCBI Official Full Name
complement component C8 beta chain isoform 1 preproprotein
NCBI Official Synonym Full Names
complement C8 beta chain
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
complement component C8 beta chain
UniProt Protein Name
Complement component C8 beta chain
UniProt Synonym Protein Names
Complement component 8 subunit beta
Protein Family
UniProt Gene Name
UniProt Entry Name
CO8B_HUMAN
NCBI Summary for C8B
This gene encodes one of the three subunits of the complement component 8 (C8) protein. C8 is composed of equimolar amounts of alpha, beta and gamma subunits, which are encoded by three separate genes. C8 is one component of the membrane attack complex, which mediates cell lysis, and it initiates membrane penetration of the complex. This protein mediates the interaction of C8 with the C5b-7 membrane attack complex precursor. In humans deficiency of this protein is associated with increased risk of meningococcal infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
UniProt Comments for C8B
C8B: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Defects in C8B are a cause of complement component 8 deficiency type 2 (C8D2). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p32.2

Cellular Component: extracellular region; membrane

Biological Process: complement activation; immune response; regulation of complement activation

Disease: Complement Component 8 Deficiency, Type Ii
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-C8B antibody
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