NP_001003962.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,316 Da
NCBI Official Full Name
calpain small subunit 1 isoform 1
NCBI Official Synonym Full Names
calpain small subunit 1
NCBI Official Synonym Symbols
CANP; CDPS; CSS1; CANPS; CAPN4; CALPAIN4 [Similar Products]
NCBI Protein Information
calpain small subunit 1
UniProt Protein Name
Calpain small subunit 1
UniProt Synonym Protein Names
Calcium-activated neutral proteinase small subunit; CANP small subunit; Calcium-dependent protease small subunit; CDPS; Calcium-dependent protease small subunit 1; Calpain regulatory subunit
UniProt Synonym Gene Names
UniProt Entry Name
CPNS1_HUMAN
NCBI Summary for CAPNS1
This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
UniProt Comments for CAPNS1
CAPNS1: Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
Protein type: Protease; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 19q13.12
Cellular Component: cytosol; membrane
Molecular Function: calcium-dependent cysteine-type endopeptidase activity; protein binding
Biological Process: extracellular matrix disassembly; positive regulation of cell proliferation
Research Articles on CAPNS1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-CAPNS1 antibody
Pathways associated with anti-CAPNS1 antibody
Diseases associated with anti-CAPNS1 antibody
Organs/Tissues associated with anti-CAPNS1 antibody
|