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anti-CCT8 antibody :: Rabbit anti-Human, Mouse CCT8 Polyclonal Antibody

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Catalog # MBS9606015
Unit / Price
  0.1 mL  /  $255 +1 FREE 8GB USB
  0.2 mL  /  $295 +1 FREE 8GB USB
Product Name

CCT8, Polyclonal Antibody

Popular Item
Also Known As

CCT8 Antibody

Product Synonym Names
C21orf112; CCT 8; CCT theta; CCT8; CCTQ; Chaperonin containing TCP1 subunit 8 (theta); Chaperonin subunit 8 (Theta) (Predicted), isoform CRA_a; Chaperonin subunit 8 (theta); Chromosome 21 open reading frame 112; D21S246; KIAA0002; PRED71; Renal carcinoma antigen NY REN 15; T complex protein 1 subunit theta; T complex protein 1 theta subunit; TCP 1 theta; Tcpq
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
529
3D Structure
ModBase 3D Structure for P50990
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Specificity
CCT8 antibody detects endogenous levels of total CCT8
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
A synthesized peptide
Subcellular Location
Cytoplasm. Cytoplasm; Cytoskeleton; Centrosome
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-CCT8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CCT8 antibody
Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.
Subunit Structure: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8. Interacts with DNAAF4 (By similarity).
Similarity: Belongs to the TCP-1 chaperonin family.
Applications Tested/Suitable for anti-CCT8 antibody
Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)
Application Notes for anti-CCT8 antibody
WB: 1:500-1:1000
IF/ICC: 1:100-1:500

Western Blot (WB) of anti-CCT8 antibody
Western blot analysis of extracts from HeLa cells, using CCT8 antibody.The lane on the left is treated with the antigen-specific peptide.
anti-CCT8 antibody Western Blot (WB) (WB) image
Immunofluorescene (IF) of anti-CCT8 antibody
MBS9606015 staining HeLa by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25 degree C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37 degree C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
anti-CCT8 antibody Immunofluorescene (IF) image
NCBI/Uniprot data below describe general gene information for CCT8. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 59 kD
Predicted: 60 kDa
NCBI Official Full Name
T-complex protein 1 subunit theta isoform 2
NCBI Official Synonym Full Names
chaperonin containing TCP1 subunit 8
NCBI Official Symbol
NCBI Official Synonym Symbols
Cctq; PRED71; D21S246; C21orf112
  [Similar Products]
NCBI Protein Information
T-complex protein 1 subunit theta
UniProt Protein Name
T-complex protein 1 subunit theta
UniProt Synonym Protein Names
CCT-theta; Chaperonin containing T-complex polypeptide 1 subunit 8; Renal carcinoma antigen NY-REN-15
UniProt Gene Name
UniProt Synonym Gene Names
C21orf112; CCTQ; KIAA0002; TCP-1-theta  [Similar Products]
NCBI Summary for CCT8
This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1. [provided by RefSeq, Sep 2013]
UniProt Comments for CCT8
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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