NP_001756.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
37,654 Da
NCBI Official Full Name
T-cell surface glycoprotein CD1c
NCBI Official Synonym Full Names
CD1c molecule
NCBI Protein Information
T-cell surface glycoprotein CD1c
UniProt Protein Name
T-cell surface glycoprotein CD1c
UniProt Synonym Protein Names
CD_antigen: CD1c
NCBI Summary for CD1C
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq, Jul 2008]
UniProt Comments for CD1C
CD1C: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q23.1
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: beta-2-microglobulin binding; endogenous lipid antigen binding; exogenous lipid antigen binding; glycolipid binding
Biological Process: antigen processing and presentation, exogenous lipid antigen via MHC class Ib; regulation of immune response; T cell activation during immune response
Research Articles on CD1C
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Products associated with anti-CD1C antibody
Pathways associated with anti-CD1C antibody
Diseases associated with anti-CD1C antibody
Organs/Tissues associated with anti-CD1C antibody
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