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anti-CERK antibody :: Rabbit anti-Human, Mouse CERK Polyclonal Antibody

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Catalog # MBS7047905
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

CERK, Polyclonal Antibody

Popular Item
Also Known As

CERK Antibody

Product Synonym Names
Ceramide kinase; hCERK; Acylsphingosine kinase; Lipid kinase 4; LK4; CERK; KIAA1646
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
537
OMIM
AB079066 mRNA
3D Structure
ModBase 3D Structure for Q8TCT0
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Immunogen
Recombinant Human Ceramide kinase protein (212-478AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, PH 7.4
Conjugation
Non-conjugated
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-79406 / sc-79409 / sc-98700
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-CERK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CERK antibody
Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides.
Applications Tested/Suitable for anti-CERK antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-CERK antibody
WB: 1: 500-1: 5000
IHC: 1: 20-1: 200
IF: 1: 50-1: 200

Western Blot (WB) of anti-CERK antibody
Western Blot
Positive WB detected in: Mouse heart tissue,Mouse lung tissue,Mouse kidney tissue
All lanes: CERK antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 60,38 kDa
Observed band size:60,48 kDa

anti-CERK antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-CERK antibody
Immunohistochemistry of paraffin-embedded human colon cancer using MBS7047905 at dilution of 1:100
anti-CERK antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-CERK antibody
Immunohistochemistry of paraffin-embedded human pancreatic cancer using MBS7047905 at dilution of 1:100
anti-CERK antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-CERK antibody
Immunofluorescent analysis of HepG2 cells using MBS7047905 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-CERK antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for CERK. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
37,781 Da
NCBI Official Full Name
ceramide kinase
NCBI Official Synonym Full Names
ceramide kinase
NCBI Official Symbol
NCBI Official Synonym Symbols
LK4; hCERK; dA59H18.2; dA59H18.3
  [Similar Products]
NCBI Protein Information
ceramide kinase
UniProt Protein Name
Ceramide kinase
UniProt Synonym Protein Names
Acylsphingosine kinase; Lipid kinase 4; LK4
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
KIAA1646; hCERK; LK4  [Similar Products]
UniProt Entry Name
CERK1_HUMAN
NCBI Summary for CERK
CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008]
UniProt Comments for CERK
CERK: Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides.

Protein type: EC 2.7.1.138; Kinase, lipid; Lipid Metabolism - sphingolipid

Chromosomal Location of Human Ortholog: 22q13.31

Cellular Component: integral to membrane; plasma membrane

Molecular Function: ceramide kinase activity; magnesium ion binding; protein binding

Biological Process: ceramide metabolic process; glycosphingolipid metabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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