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anti-HSD11B1 antibody :: Rabbit anti-Human, Mouse Corticosteroid 11-beta-dehydrogenase isozyme 1 Polyclonal Antibody

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Catalog # MBS1493323
Unit / Price
  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

Corticosteroid 11-beta-dehydrogenase isozyme 1 (HSD11B1), Polyclonal Antibody

Popular Item
Also Known As

Rabbit anti-human Corticosteroid 11-beta-dehydrogenase isozyme 1 polyclonal Antibody(HSD11B1)

Product Synonym Names
11-beta-hydroxysteroid dehydrogenase 1; 11-DH; 11-beta-HSD1; HSD11B1; HSD11; HSD11L
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
292
OMIM
600713
3D Structure
ModBase 3D Structure for P28845
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Corticosteroid 11-beta-dehydrogenase isozyme 1 protein (25-292aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-19259 / sc-19257 / sc-20175
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-HSD11B1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-HSD11B1 antibody
Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol.
Applications Tested/Suitable for anti-HSD11B1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-HSD11B1 antibody
Recommended dilution: WB:1:500-2000
IHC:1:20-1:200

Western Blot (WB) of anti-HSD11B1 antibody
All lanes: Corticosteroid 11-beta-dehydrogenase isozyme 1 antibody at 7ug/ml
Lane 1:mouse liver tissue
Lane 2:Jurkat whole cell lysate
Lane 2:LO2 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 32kDa
Observed band size: 32kDa

anti-HSD11B1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-HSD11B1 antibody
Immunohistochemistry of paraffin-embedded human liver using MBS1493323 at dilution 1:100
anti-HSD11B1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-HSD11B1 antibody
Immunohistochemistry of paraffin-embedded human adrenal gland using MBS1493323 at dilution 1:100
anti-HSD11B1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for HSD11B1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
32,401 Da
NCBI Official Full Name
corticosteroid 11-beta-dehydrogenase isozyme 1
NCBI Official Synonym Full Names
hydroxysteroid (11-beta) dehydrogenase 1
NCBI Official Symbol
HSD11B1  [Similar Products]
NCBI Official Synonym Symbols
HDL; 11-DH; HSD11; HSD11B; HSD11L; CORTRD2; SDR26C1; 11-beta-HSD1
  [Similar Products]
NCBI Protein Information
corticosteroid 11-beta-dehydrogenase isozyme 1
UniProt Protein Name
Corticosteroid 11-beta-dehydrogenase isozyme 1
UniProt Synonym Protein Names
11-beta-hydroxysteroid dehydrogenase 1; 11-DH; 11-beta-HSD1; Short chain dehydrogenase/reductase family 26C member 1
UniProt Gene Name
HSD11B1  [Similar Products]
UniProt Synonym Gene Names
HSD11; HSD11L; SDR26C1; 11-DH; 11-beta-HSD1  [Similar Products]
UniProt Entry Name
DHI1_HUMAN
NCBI Summary for HSD11B1
The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011]
UniProt Comments for HSD11B1
HSD11B1: Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol. Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD). In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS). Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Protein type: Lipid Metabolism - C21-steroid hormone; Oxidoreductase; Endoplasmic reticulum; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; EC 1.1.1.146

Chromosomal Location of Human Ortholog: 1q32-q41

Cellular Component: endoplasmic reticulum membrane; integral to membrane; membrane

Molecular Function: 11-beta-hydroxysteroid dehydrogenase activity

Biological Process: glucocorticoid biosynthetic process; lung development; steroid metabolic process

Disease: Cortisone Reductase Deficiency 2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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