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anti-CPN1 antibody :: Rabbit anti-Human, Mouse CPN1 Polyclonal Antibody

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Catalog # MBS7045345
Unit / Price
  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

CPN1, Polyclonal Antibody

Popular Item
Full Product Name

CPN1 Antibody

Product Synonym Names
Carboxypeptidase N catalytic chain; CPN; Anaphylatoxin inactivator; Arginine carboxypeptidase; Carboxypeptidase N polypeptide 1; Carboxypeptidase N small subunit; Kininase-1; Lysine carboxypeptidase; Plasma carboxypeptidase B; Serum carboxypeptidase N; SCPN; CPN1; ACBP
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
212070
3D Structure
ModBase 3D Structure for P15169
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
Antigen Affinity Purified
Form/Format
Liquid
Species
Human
Immunogen
Recombinant human Carboxypeptidase N catalytic chain protein (C-250AA)
Conjugate
Non-conjugated
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-18966
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-CPN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CPN1 antibody
Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.
Applications Tested/Suitable for anti-CPN1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western Blot (WB) of anti-CPN1 antibody
Western blot
All lanes: CPN1 antibody at 6.19ug/ml
Lane 1: Mouse liver tissue
Lane 2: MCF7 whole cell lysate
Lane 3: HepG-2 whole cell lysate
Goat polyclonal to Rabbit IgG at 1/10000 dilution
Predicted band size: 52 kDa
Observed band size: 52 kDa

anti-CPN1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-CPN1 antibody
Immunohistochemistry of paraffin-embedded human liver tissue using MBS7045345 at dilution 1:100
anti-CPN1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-CPN1 antibody
Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7045345 at dilution 1:100
anti-CPN1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for CPN1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
52,286 Da
NCBI Official Full Name
carboxypeptidase N catalytic chain
NCBI Official Synonym Full Names
carboxypeptidase N subunit 1
NCBI Official Symbol
NCBI Official Synonym Symbols
CPN; SCPN
  [Similar Products]
NCBI Protein Information
carboxypeptidase N catalytic chain
UniProt Protein Name
Carboxypeptidase N catalytic chain
UniProt Synonym Protein Names
Anaphylatoxin inactivator; Arginine carboxypeptidase; Carboxypeptidase N polypeptide 1; Carboxypeptidase N small subunit; Kininase-1; Lysine carboxypeptidase; Plasma carboxypeptidase B; Serum carboxypeptidase N; SCPN
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
ACBP; CPN; SCPN  [Similar Products]
UniProt Entry Name
CBPN_HUMAN
NCBI Summary for CPN1
Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008]
UniProt Comments for CPN1
CPN1: Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation. Defects in CPN1 are the cause of carboxypeptidase N deficiency (CPND). Patients affected present some combination of angioedema or chronic urticaria, as well as hay fever or astma, and have also slightly depressed serum carboxy peptidase N, suggestive of autosomal recessive inheritance of this disorder. Belongs to the peptidase M14 family.

Protein type: Secreted; Protease; EC 3.4.17.3; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10q24.2

Molecular Function: serine carboxypeptidase activity

Biological Process: peptide metabolic process; protein processing

Disease: Carboxypeptidase N Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-CPN1 antibody
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