NP_001104515.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
cyclin-A1 isoform b
NCBI Official Synonym Full Names
cyclin A1
NCBI Official Synonym Symbols
NCBI Protein Information
cyclin-A1
UniProt Protein Name
Cyclin-A1
UniProt Entry Name
CCNA1_HUMAN
NCBI Summary for CCNA1
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CCNA1
CCNA1: May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. Belongs to the cyclin family. Cyclin AB subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor co-regulator; Cancer Testis Antigen (CTA); Cell cycle regulation
Chromosomal Location of Human Ortholog: 13q12.3-q13
Cellular Component: microtubule cytoskeleton; nucleoplasm; cytosol
Molecular Function: protein binding; protein kinase binding
Biological Process: G1/S-specific transcription in mitotic cell cycle; mitosis; male meiosis I; cell division; regulation of G2/M transition of mitotic cell cycle; spermatogenesis; mitotic cell cycle; regulation of cyclin-dependent protein kinase activity; G2/M transition of mitotic cell cycle; G1/S transition of mitotic cell cycle
Research Articles on CCNA1
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Products associated with anti-CCNA1 antibody
Pathways associated with anti-CCNA1 antibody
Diseases associated with anti-CCNA1 antibody
Organs/Tissues associated with anti-CCNA1 antibody
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