NP_001182344.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 82 kDa Predicted: 83 kDa
NCBI Official Full Name
serine/threonine-protein kinase DCLK1 isoform 2
NCBI Official Synonym Full Names
doublecortin like kinase 1
NCBI Official Synonym Symbols
CL1; DCLK; CLICK1; DCDC3A; DCAMKL1 [Similar Products]
NCBI Protein Information
serine/threonine-protein kinase DCLK1
UniProt Protein Name
Serine/threonine-protein kinase DCLK1
UniProt Synonym Protein Names
Doublecortin domain-containing protein 3A; Doublecortin-like and CAM kinase-like 1; Doublecortin-like kinase 1
UniProt Synonym Gene Names
NCBI Summary for DCLK1
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]
UniProt Comments for DCLK1
Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.
Research Articles on DCLK1
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Products associated with anti-DCLK1 antibody
Diseases associated with anti-DCLK1 antibody
Organs/Tissues associated with anti-DCLK1 antibody
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