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anti-DISC1 antibody :: Rabbit anti-Human, Mouse DISC1 Polyclonal Antibody

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Catalog # MBS151155
Unit / Price
  0.1 mg  /  $375 +1 FREE 8GB USB
Product Name

DISC1, Polyclonal Antibody

Also Known As

DISC1 Antibody

Product Synonym Names
DISC1; SCZD9; C1orf136; KIAA0457; Disrupted in schizophrenia 1 protein; disrupted in schizophrenia 1
Antibody/Peptide Pairs
DISC1 peptide (MBS152422) is used for blocking the activity of DISC1 antibody (MBS151155)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
854
OMIM
phenotype 605210
3D Structure
ModBase 3D Structure for Q9NRI5
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
DISC1 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (lot specific)
Conjugate
Unconjugated
Immunogen
DISC1 antibody was raised against a 18 amino acid synthetic peptide from near the center of human DISC1.
Buffer
DISC1 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
DISC1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Other Notes
Small volumes of anti-DISC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DISC1 antibody
DISC1 Antibody: Disrupted in schizophrenia 1 (DISC1) is a candidate gene for susceptibility to schizophrenia. It was discovered through chromosomal analysis of a large Scottish family whose members exhibited schizophrenia and related psychiatric disorders. Through yeast two-hybrid screening, it was discovered that DISC1 interacts with many members of the centrosome and cytoskeletal system including MAP1A and Nudel. More recently, DISC1 has been found to regulate the transport of a complex containing Nudel, the lissencephaly-1 (LIS1) protein, and 14-3-3epsilon from neuronal cell bodies to the axons by the action of the microtubule-dependent directed motor protein kinesin-1, also known as KIF5A. Decreased expression of DISC1 in neurons caused an accelerated rate of neuronal integration, resulting in aberrant morphological development, suggesting that DISC1 plays a role in dendritic development and synapse formation. DISC1 has at least four known isoforms.
Applications Tested/Suitable for anti-DISC1 antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-DISC1 antibody
DISC1 antibody can be used for detection of DISC1 by Western blot at 0.5 - 2 mug/mL. Antibody can also be used for immunocytochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-DISC1 antibody
Western blot analysis of DISC1 in SK-N-SH cell lysate with DISC1 antibody at (A) 0.5, (B) 1 and (C) 2 μg/mL.
anti-DISC1 antibody Western Blot (WB) (WB) image
Immunocytochemistry (ICC) of anti-DISC1 antibody
Immunocytochemistry of DISC1 in HeLa cells with DISC1 antibody at 5 μg/mL.
anti-DISC1 antibody Immunocytochemistry (ICC) (ICC) image
Immunofluorescence (IF) of anti-DISC1 antibody
Immunofluorescence of DISC1 in Hela cells with DISC1 antibody at 20 μg/mL.
anti-DISC1 antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for DISC1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,198 Da
NCBI Official Full Name
disrupted in schizophrenia 1 protein isoform L
NCBI Official Synonym Full Names
disrupted in schizophrenia 1
NCBI Official Symbol
DISC1  [Similar Products]
NCBI Official Synonym Symbols
SCZD9; C1orf136
  [Similar Products]
NCBI Protein Information
disrupted in schizophrenia 1 protein
UniProt Protein Name
Disrupted in schizophrenia 1 protein
UniProt Gene Name
DISC1  [Similar Products]
UniProt Synonym Gene Names
KIAA0457  [Similar Products]
UniProt Entry Name
DISC1_HUMAN
NCBI Summary for DISC1
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for DISC1
DISC1: Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation. A chromosomal aberration involving DISC1 segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Translocation t(1;11)(q42.1;q14.3). The truncated DISC1 protein produced by this translocation is unable to interact with ATF4, ATF5 and NDEL1. Genetic variation in DISC1 is associated with susceptibility to schizophrenia type 9 (SCZD9). A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q42.1

Cellular Component: postsynaptic membrane; microtubule; centrosome; mitochondrion; postsynaptic density; cell junction

Molecular Function: protein binding

Biological Process: positive regulation of neuroblast proliferation; mitochondrial calcium ion homeostasis; TOR signaling pathway; cell proliferation in forebrain; neuron migration; cerebral cortex radially oriented cell migration; Wnt receptor signaling pathway through beta-catenin; microtubule cytoskeleton organization and biogenesis; positive regulation of Wnt receptor signaling pathway

Disease: Schizophrenia; Schizophrenia 9
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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