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Rabbit anti-Mouse, human DsbA-L (Disulfide-bond-A oxidoreductase-like protein) Polyclonal Antibody

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Catalog # MBS502156
Unit / Price
  0.1 mL  /  $315 +1 FREE 8GB USB
Testing Data
Product Name

DsbA-L (Disulfide-bond-A oxidoreductase-like protein), Polyclonal Antibody

Full Product Name


Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Mouse, human
Specific for the ~25 kDa DsbA-L protein in Western blots of 3T3-L1 adipocytes and mouse white and brown adipose tissue lysate samples. It is suggested that you add 1% BSA to the antibody dilution buffer.
Liquid in 40% glycerol.
Full length recombinant mouse DsbA-L protein.
Immunogen Information
Full length recombinant mouse DsbA-L protein
Immunogen Species
Species Reactivity Note
The antibody has been directly tested for reactivity in mouse and human. Other species have not been tested.
Biological Significance
Disulfide-bond-A oxidoreductase-like protein (DsbA-L, previously named as GST Kappa) is an adiponectin-interacting protein. DsbA-L is highly expressed in adipose tissue, and its expression level is negatively correlated with obesity in mice and humans. DsbA-L expression in 3T3-L1 adipocytes is stimulated by the insulin sensitizer rosiglitazone and inhibited by the inflammatory cytokine TNFalpha. Polymorphism of DsbA-L gene has recently been implicated in insulin secretion and body fat distribution (Gao F et al., 2009). Overexpression of DsbA-L promotes adiponectin multimerization while suppressing DsbA-L expression by RNAi markedly and selectively reduces adiponectin levels and secretion in 3T3-L1 adipocytes. Recent studies identify DsbA-L as a key regulator for adiponectin biosynthesis (Liu et al., 2008).
Preparation and Storage
Store at -20 degree C in undiluted aliquots; stable for at least 1 year after date of receipt. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-DsbA-L (Disulfide-bond-A oxidoreductase-like protein) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Rabbit polyclonal antibody
Western Blot (WB), Immunohistochemistry (IHC)
Quality Control: Western blots performed on each lot.
WB: 1:2000
IHC: 1:200

Molecular Weight
• Polymorphism of DsbA-L gene associates with insulin secretion and body fat distribution in Chinese population. (2009) Gao F, Fang Q, Zhang R, Lu J, Lu H, Wang C, Ma X, Xu J, Jia W, Xiang K. Endocr J. Jun;56(3):487-94.
• Liu et al, (2008) A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization. Proc Natl Acad Sci USA, 105, 18302-18307.
• Wang A, Liu M, Liu X, Dong LQ, Glickman RD, Slaga TJ, Zhou Z, Liu F (2011) Up-regulation of Adiponectin by Resveratrol: THE ESSENTIAL ROLES OF THE Akt/FOXO1 AND AMPACTIVATED PROTEIN KINASE SIGNALING PATHWAYS AND DsbA-L. J Biol Chem. Jan 7;286(1):60-6.

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