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Rabbit anti-Mouse, human DsbA-L (Disulfide-bond-A oxidoreductase-like protein) Polyclonal Antibody

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Catalog # MBS502156
Unit / Price
  0.1 mL  /  $315 +1 FREE 8GB USB
Testing Data
Product Name

DsbA-L (Disulfide-bond-A oxidoreductase-like protein), Polyclonal Antibody

Full Product Name

Anti-DsbA-L

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, human
Specificity
Specific for the ~25 kDa DsbA-L protein in Western blots of 3T3-L1 adipocytes and mouse white and brown adipose tissue lysate samples. It is suggested that you add 1% BSA to the antibody dilution buffer.
Purity/Purification
Serum
Form/Format
Liquid in 40% glycerol.
Antigen
Full length recombinant mouse DsbA-L protein.
Immunogen Information
Full length recombinant mouse DsbA-L protein
Immunogen Species
Mouse
Species Reactivity Note
The antibody has been directly tested for reactivity in mouse and human. Other species have not been tested.
Biological Significance
Disulfide-bond-A oxidoreductase-like protein (DsbA-L, previously named as GST Kappa) is an adiponectin-interacting protein. DsbA-L is highly expressed in adipose tissue, and its expression level is negatively correlated with obesity in mice and humans. DsbA-L expression in 3T3-L1 adipocytes is stimulated by the insulin sensitizer rosiglitazone and inhibited by the inflammatory cytokine TNFalpha. Polymorphism of DsbA-L gene has recently been implicated in insulin secretion and body fat distribution (Gao F et al., 2009). Overexpression of DsbA-L promotes adiponectin multimerization while suppressing DsbA-L expression by RNAi markedly and selectively reduces adiponectin levels and secretion in 3T3-L1 adipocytes. Recent studies identify DsbA-L as a key regulator for adiponectin biosynthesis (Liu et al., 2008).
Preparation and Storage
Store at -20 degree C in undiluted aliquots; stable for at least 1 year after date of receipt. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-DsbA-L (Disulfide-bond-A oxidoreductase-like protein) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Rabbit polyclonal antibody
Western Blot (WB), Immunohistochemistry (IHC)
Quality Control: Western blots performed on each lot.
WB: 1:2000
IHC: 1:200

Molecular Weight
• Polymorphism of DsbA-L gene associates with insulin secretion and body fat distribution in Chinese population. (2009) Gao F, Fang Q, Zhang R, Lu J, Lu H, Wang C, Ma X, Xu J, Jia W, Xiang K. Endocr J. Jun;56(3):487-94.
• Liu et al, (2008) A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization. Proc Natl Acad Sci USA, 105, 18302-18307.
• Wang A, Liu M, Liu X, Dong LQ, Glickman RD, Slaga TJ, Zhou Z, Liu F (2011) Up-regulation of Adiponectin by Resveratrol: THE ESSENTIAL ROLES OF THE Akt/FOXO1 AND AMPACTIVATED PROTEIN KINASE SIGNALING PATHWAYS AND DsbA-L. J Biol Chem. Jan 7;286(1):60-6.

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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