NP_054799.4
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
dual oxidase 2
NCBI Official Synonym Full Names
dual oxidase 2
NCBI Official Synonym Symbols
TDH6; LNOX2; THOX2; NOXEF2; P138-TOX [Similar Products]
NCBI Protein Information
dual oxidase 2
UniProt Protein Name
Dual oxidase 2
UniProt Synonym Protein Names
Large NOX 2; Long NOX 2; NADH/NADPH thyroid oxidase p138-tox; NADPH oxidase/peroxidase DUOX2; NADPH thyroid oxidase 2; Thyroid oxidase 2; p138 thyroid oxidase
UniProt Synonym Gene Names
UniProt Entry Name
DUOX2_HUMAN
NCBI Summary for DUOX2
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. [provided by RefSeq, Jul 2008]
UniProt Comments for DUOX2
DUOX2: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. Defects in DUOX2 are a cause of thyroid dyshormonogenesis 6 (TDH6). A disorder due to a defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.
Protein type: EC 1.6.3.1; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase
Chromosomal Location of Human Ortholog: 15q15.3
Cellular Component: plasma membrane
Molecular Function: calcium ion binding; NAD(P)H oxidase activity
Biological Process: cuticle development; cytokine and chemokine mediated signaling pathway; response to cAMP; response to virus; thyroid hormone generation
Disease: Thyroid Dyshormonogenesis 6
Research Articles on DUOX2
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Pathways associated with anti-DUOX2 antibody
Diseases associated with anti-DUOX2 antibody
Organs/Tissues associated with anti-DUOX2 antibody
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