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anti-EDNRB antibody :: Rabbit anti-Human, Mouse EDNRB Polyclonal Antibody

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Catalog # MBS7048061
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

EDNRB, Polyclonal Antibody

Popular Item
Full Product Name

EDNRB Antibody

Product Synonym Names
Endothelin B receptor; ET-B; ET-BR; Endothelin receptor non-selective type; EDNRB; ETRB
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
M74921 mRNA
3D Structure
ModBase 3D Structure for P24530
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Immunogen
Recombinant Human Endothelin B receptor protein (27-442AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4
Conjugation
Non-conjugated
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-21195 / sc-21196 / sc-21197 / sc-21199 / sc-33537
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-EDNRB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-EDNRB antibody
Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Applications Tested/Suitable for anti-EDNRB antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-EDNRB antibody
WB: 1: 500-1: 5000
IHC: 1: 20-1: 200
IF: 1: 50-1: 200

Western Blot (WB) of anti-EDNRB antibody
Western Blot
Positive WB detected in: Mouse heart tissue,Mouse skeletal muscle tissue
All lanes: EDNRB antibody at 4ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 50,49,60 KDa
Observed band size: 50 KDa

anti-EDNRB antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-EDNRB antibody
Immunohistochemistry of paraffin-embedded human lung tissue using MBS7048061 at dilution of 1:100
anti-EDNRB antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-EDNRB antibody
Immunofluorescent analysis of PC3 cells using MBS7048061 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-EDNRB antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for EDNRB. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,480 Da
NCBI Official Full Name
endothelin B receptor isoform 1
NCBI Official Synonym Full Names
endothelin receptor type B
NCBI Official Symbol
EDNRB  [Similar Products]
NCBI Official Synonym Symbols
ETB; ET-B; ETB1; ETBR; ETRB; HSCR; WS4A; ABCDS; ET-BR; HSCR2
  [Similar Products]
NCBI Protein Information
endothelin B receptor
UniProt Protein Name
Endothelin B receptor
UniProt Synonym Protein Names
Endothelin receptor non-selective type
Protein Family
UniProt Gene Name
EDNRB  [Similar Products]
UniProt Synonym Gene Names
ETRB; ET-B; ET-BR  [Similar Products]
UniProt Entry Name
EDNRB_HUMAN
NCBI Summary for EDNRB
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]
UniProt Comments for EDNRB
ETB: a G protein-coupled receptor which activates a phosphatidylinoitol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutation in endothelin receptor type B gene. Essential component in the normal development of two neuronal crest-derived cell lineages. Two splice variant isoforms have been described.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 13q22

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: endothelin receptor activity; peptide hormone binding; protein binding

Biological Process: cell surface receptor linked signal transduction; enteric nervous system development; macrophage chemotaxis; negative regulation of adenylate cyclase activity; negative regulation of cellular protein metabolic process; negative regulation of neuron maturation; negative regulation of transcription from RNA polymerase II promoter; nervous system development; vasoconstriction; vein smooth muscle contraction

Disease: Abcd Syndrome; Hirschsprung Disease, Susceptibility To, 2; Waardenburg Syndrome, Type 4a
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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