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anti-EDNRB antibody :: Rabbit anti-Human, Mouse EDNRB Polyclonal Antibody

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Catalog # MBS7048061
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

EDNRB, Polyclonal Antibody

Popular Item
Full Product Name

EDNRB Antibody

Product Synonym Names
Endothelin B receptor; ET-B; ET-BR; Endothelin receptor non-selective type; EDNRB; ETRB
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
M74921 mRNA
3D Structure
ModBase 3D Structure for P24530
Species Reactivity
Human, Mouse
>95%, Protein G purified
Recombinant Human Endothelin B receptor protein (27-442AA)
0.03% Proclin 300
50% Glycerol, 0.01M PBS, pH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-21195 / sc-21196 / sc-21197 / sc-21199 / sc-33537
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-EDNRB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-EDNRB antibody
Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Applications Tested/Suitable for anti-EDNRB antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-EDNRB antibody
WB: 1: 500-1: 5000
IHC: 1: 20-1: 200
IF: 1: 50-1: 200

Western Blot (WB) of anti-EDNRB antibody
Western Blot
Positive WB detected in: Mouse heart tissue,Mouse skeletal muscle tissue
All lanes: EDNRB antibody at 4ug/ml
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 50,49,60 KDa
Observed band size: 50 KDa

anti-EDNRB antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-EDNRB antibody
Immunohistochemistry of paraffin-embedded human lung tissue using MBS7048061 at dilution of 1:100
anti-EDNRB antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-EDNRB antibody
Immunofluorescent analysis of PC3 cells using MBS7048061 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-EDNRB antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for EDNRB. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,480 Da
NCBI Official Full Name
endothelin B receptor isoform 1
NCBI Official Synonym Full Names
endothelin receptor type B
NCBI Official Symbol
EDNRB  [Similar Products]
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
endothelin B receptor
UniProt Protein Name
Endothelin B receptor
UniProt Synonym Protein Names
Endothelin receptor non-selective type
Protein Family
UniProt Gene Name
EDNRB  [Similar Products]
UniProt Synonym Gene Names
ETRB; ET-B; ET-BR  [Similar Products]
UniProt Entry Name
NCBI Summary for EDNRB
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]
UniProt Comments for EDNRB
ETB: a G protein-coupled receptor which activates a phosphatidylinoitol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutation in endothelin receptor type B gene. Essential component in the normal development of two neuronal crest-derived cell lineages. Two splice variant isoforms have been described.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 13q22

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: endothelin receptor activity; peptide hormone binding; protein binding

Biological Process: cell surface receptor linked signal transduction; enteric nervous system development; macrophage chemotaxis; negative regulation of adenylate cyclase activity; negative regulation of cellular protein metabolic process; negative regulation of neuron maturation; negative regulation of transcription from RNA polymerase II promoter; nervous system development; vasoconstriction; vein smooth muscle contraction

Disease: Abcd Syndrome; Hirschsprung Disease, Susceptibility To, 2; Waardenburg Syndrome, Type 4a
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