NP_001229757.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 28 kD Predicted: 36 kDa
NCBI Official Full Name
elongation of very long chain fatty acids protein 5 isoform 2
NCBI Official Synonym Full Names
ELOVL fatty acid elongase 5
NCBI Protein Information
elongation of very long chain fatty acids protein 5
UniProt Protein Name
Elongation of very long chain fatty acids protein 5
UniProt Synonym Protein Names
3-keto acyl-CoA synthase ELOVL5UniRule annotationManual assertion according to rulesiHAMAP-Rule:MF_03205; ELOVL fatty acid elongase 5UniRule annotationManual assertion according to rulesiHAMAP-Rule:MF_03205; ELOVL FA elongase 5UniRule annotationManual assertion according to rulesiHAMAP-Rule:MF_03205; Fatty acid elongase 1; hELO1; Very long chain 3-ketoacyl-CoA synthase 5UniRule annotationManual assertion according to rulesiHAMAP-Rule:MF_03205; Very long chain 3-oxoacyl-CoA synthase 5UniRule annotationManual assertion according to rulesiHAMAP-Rule:MF_03205
UniProt Synonym Gene Names
NCBI Summary for ELOVL5
This gene belongs to the ELO family. It is highly expressed in the adrenal gland and testis, and encodes a multi-pass membrane protein that is localized in the endoplasmic reticulum. This protein is involved in the elongation of long-chain polyunsaturated fatty acids. Mutations in this gene have been associated with spinocerebellar ataxia-38 (SCA38). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
UniProt Comments for ELOVL5
Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Research Articles on ELOVL5
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Pathways associated with anti-ELOVL5 antibody
Products by Pathway |
Pathway Diagram |
Biosynthesis Of Unsaturated Fatty Acids Pathway antibodies |
Biosynthesis Of Unsaturated Fatty Acids Pathway Diagram |
Biosynthesis Of Unsaturated Fatty Acids Pathway antibodies |
Biosynthesis Of Unsaturated Fatty Acids Pathway Diagram |
Fatty Acyl-CoA Biosynthesis Pathway antibodies |
Fatty Acyl-CoA Biosynthesis Pathway Diagram |
Fatty Acid Biosynthesis, Elongation, Endoplasmic Reticulum Pathway antibodies |
Fatty Acid Biosynthesis, Elongation, Endoplasmic Reticulum Pathway Diagram |
Fatty Acid Biosynthesis, Elongation, Endoplasmic Reticulum Pathway antibodies |
Fatty Acid Biosynthesis, Elongation, Endoplasmic Reticulum Pathway Diagram |
Fatty Acid Elongation Pathway antibodies |
Fatty Acid Elongation Pathway Diagram |
Fatty Acid Elongation Pathway antibodies |
Fatty Acid Elongation Pathway Diagram |
Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies |
Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram |
Linoleic Acid (LA) Metabolism Pathway antibodies |
Linoleic Acid (LA) Metabolism Pathway Diagram |
Metabolism Pathway antibodies |
Metabolism Pathway Diagram |
Diseases associated with anti-ELOVL5 antibody
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