• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-Fgfr1 antibody :: Rabbit anti-Human, mouse Fgfr1 Polyclonal Antibody

Scan QR to view Datasheet
Catalog # MBS9209911
Unit / Price
Scan QR to view Datasheet
  0.08 mL  /  $165 +1 FREE 8GB USB
  0.4 mL  /  $370 +1 FREE 8GB USB
Product Name

Fgfr1, Polyclonal Antibody

Popular Item
Full Product Name

Mouse Fgfr1 Antibody (C-term)

Product Synonym Names
Fibroblast growth factor receptor 1; FGFR-1; bFGF-R-1; Basic fibroblast growth factor receptor 1; MFR; Proto-oncogene c-Fgr; CD331; Fgfr1; Flg
Antibody/Peptide Pairs
Fgfr1 peptide (MBS9221153) is used for blocking the activity of Fgfr1 antibody (MBS9209911)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
756-784
3D Structure
ModBase 3D Structure for P16092
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human, mouse
Specificity
This Mouse Fgfr1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 756-784 amino acids from the C-terminal region of mouse Fgfr1.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Antigen Type
Synthetic Peptide
Antigen Source
MOUSE
Function
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation (By similarity).
Cellular Location
Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle Note=After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus Isoform 5: Cell membrane; Single-pass type I membrane protein
Tissue Location
Widely expressed.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-Fgfr1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Fgfr1 antibody
Receptor for basic fibroblast growth factor. A shorter form of the receptor could be a receptor for FGF1 (aFGF). Receptor for FGF23 in the presence of KL.
Applications Tested/Suitable for anti-Fgfr1 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-Fgfr1 antibody
WB~~1:1000
IHC-P~~1:10~50

Western Blot (WB) of anti-Fgfr1 antibody
Mouse Fgfr1 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the Fgfr1 antibody detected the Fgfr1 protein (arrow).
anti-Fgfr1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-Fgfr1 antibody
Mouse Fgfr1 Antibody (C-term) (MBS9209911)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse adrenal glands followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Fgfr1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
anti-Fgfr1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for Fgfr1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
91981
NCBI Official Full Name
fibroblast growth factor receptor 1 isoform 2
NCBI Official Synonym Full Names
fibroblast growth factor receptor 1
NCBI Official Symbol
Fgfr1  [Similar Products]
NCBI Official Synonym Symbols
FLG; MFR; Eask; Hspy; Flt-2; c-fgr; Fgfr-1; AW208770; bFGF-R-1
  [Similar Products]
NCBI Protein Information
fibroblast growth factor receptor 1
UniProt Protein Name
Fibroblast growth factor receptor 1
UniProt Synonym Protein Names
Basic fibroblast growth factor receptor 1; MFR; Proto-oncogene c-Fgr; CD_antigen: CD331
Protein Family
UniProt Gene Name
Fgfr1  [Similar Products]
UniProt Synonym Gene Names
Flg; FGFR-1; bFGF-R-1  [Similar Products]
UniProt Entry Name
FGFR1_MOUSE
UniProt Comments for Fgfr1
FGFR1: a receptor tyrosine kinase of the highly-conserved fibroblast growth factor receptor (FGFR). Binds both acidic and basic fibroblast growth factors and is involved in limb induction. Point mutations cause Pfeffer syndrome (finger and toe malformations and other skeletal errors) and dominant Kallmann syndrome 2. Stem cell leukemia lymphoma syndrome (SCLL) may be caused by a t(8;13)(p12;q12) translocation that fuses a zinc finger gene, ZNF198, to FGFR1. Various myeloproliferative disorders have been linked to translocations that fuse FGFR1 to FOP, FIM, CEP1 or the atypical kinase, Bcr. Inhibitor: SU5402. 20 isoforms of the human protein produced by alternative splicing have been described.

Protein type: Membrane protein, integral; Kinase, protein; Protein kinase, TK; Oncoprotein; Protein kinase, tyrosine (receptor); EC 2.7.10.1; TK group; FGFR family

Cellular Component: membrane; cytoplasm; integral to membrane; plasma membrane; cytoplasmic vesicle; nucleus; receptor complex

Molecular Function: heparin binding; transferase activity; protein binding; fibroblast growth factor binding; fibroblast growth factor receptor activity; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding; protein kinase activity

Biological Process: paraxial mesoderm development; peptidyl-tyrosine phosphorylation; cell maturation; middle ear morphogenesis; negative regulation of transcription from RNA polymerase II promoter; orbitofrontal cortex development; protein amino acid phosphorylation; sensory perception of sound; ureteric bud development; induction of an organ; positive regulation of mesenchymal cell proliferation; midbrain development; positive regulation of cell proliferation; salivary gland morphogenesis; chondrocyte differentiation; angiogenesis; embryonic limb morphogenesis; positive regulation of cardiac muscle cell proliferation; inner ear morphogenesis; fibroblast growth factor receptor signaling pathway; in utero embryonic development; outer ear morphogenesis; positive regulation of cell cycle; regulation of cell proliferation; neuroblast division in the ventricular zone; mesenchymal cell differentiation; generation of neurons; regulation of gene expression; auditory receptor cell development; blood vessel morphogenesis; brain development; phosphorylation; regulation of lateral mesodermal cell fate specification; lung development
Product References and Citations for anti-Fgfr1 antibody
Drogat, B., et al. Blood 116(12):2141-2151(2010)
Bowles, J., et al. Dev. Cell 19(3):440-449(2010)
Chung, W.C., et al. J. Neuroendocrinol. 22(8):944-950(2010)
Pond, A.C., et al. Cancer Res. 70(12):4868-4879(2010)
Maruyama, T., et al. Sci Signal 3 (123), RA40 (2010) :

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000