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anti-FGF2 antibody :: Rabbit Fibroblast growth factor 2 Polyclonal Antibody

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Catalog # MBS1490134
Unit / Price
Scan QR to view Datasheet
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

Fibroblast growth factor 2 (FGF2), Polyclonal Antibody

Popular Item
Full Product Name

Rabbit anti-human Fibroblast growth factor 2 polyclonal Antibody

Product Synonym Names
FGFB; Basic fibroblast growth factor; bFGF; Heparin-binding growth factor 2; HBGF-2; FGF-2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
134920
3D Structure
ModBase 3D Structure for P09038
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse. Other species are not tested. Please decide the specificity by homology
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation Purified
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
Non-conjugated
Immunogen
Recombinant human Fibroblast growth factor 2 protein
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-1360 / sc-1390 / sc-79 / sc-7911
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-FGF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FGF2 antibody
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.
Applications Tested/Suitable for anti-FGF2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western Blot (WB) of anti-FGF2 antibody
All lanes: Fibroblast growth factor 2 antibody at 2ug/ml
Lane 1:mouse kidney tissue
Lane 2:mouse brain tissue
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 31,23,18,22 kDa
Observed band size: 31 kDa

anti-FGF2 antibody Western Blot (WB) (WB) image
Western Blot (WB) of anti-FGF2 antibody
Western blot
All lanes: FGF2 antibody at 4 ug/ml
Lane 1: HepG-2 whole cell lysate
Lane 2: Mouse heart tissue
Lane 3: Mouse liver tissue
Lane 4: Mouse lung tissue
Lane 5: Mouse kidney tissue
Lane 6: Mouse brain tissue
Lane 7: Mouse thymus tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 31,23,18,22 kDa
Observed band size: 30 kDa

anti-FGF2 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-FGF2 antibody
Immunohistochemistry of paraffin-embedded human prostate using MBS1490134 at dilution of 1:100
anti-FGF2 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-FGF2 antibody
Immunohistochemistry of paraffin-embedded mouse lung using MBS1490134 at dilution 1:100.
anti-FGF2 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for FGF2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,203 Da
NCBI Official Full Name
fibroblast growth factor 2
NCBI Official Synonym Full Names
fibroblast growth factor 2
NCBI Official Symbol
NCBI Official Synonym Symbols
BFGF; FGFB; FGF-2; HBGF-2
  [Similar Products]
NCBI Protein Information
fibroblast growth factor 2
UniProt Protein Name
Fibroblast growth factor 2
UniProt Synonym Protein Names
Basic fibroblast growth factor; bFGF; Heparin-binding growth factor 2; HBGF-2
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
FGFB; FGF-2; bFGF; HBGF-2  [Similar Products]
UniProt Entry Name
FGF2_HUMAN
NCBI Summary for FGF2
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008]
UniProt Comments for FGF2
FGF2: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2. Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non- cancerous liver tissue. Belongs to the heparin-binding growth factors family. 4 isoforms of the human protein are produced by alternative initiation.

Protein type: Motility/polarity/chemotaxis; Activator

Chromosomal Location of Human Ortholog: 4q26

Cellular Component: extracellular region; extracellular space; nucleus

Molecular Function: chemoattractant activity; cytokine activity; fibroblast growth factor receptor binding; growth factor activity; heparin binding; ligand-dependent nuclear receptor transcription coactivator activity; protein binding

Biological Process: activation of MAPK activity; activation of MAPKK activity; axon guidance; cell migration during sprouting angiogenesis; chemotaxis; embryonic morphogenesis; epidermal growth factor receptor signaling pathway; extracellular matrix organization and biogenesis; fibroblast growth factor receptor signaling pathway; growth factor dependent regulation of satellite cell proliferation; hyaluronan catabolic process; innate immune response; inositol phosphate biosynthetic process; insulin receptor signaling pathway; MAPKKK cascade; negative regulation of blood vessel endothelial cell migration; nerve growth factor receptor signaling pathway; nervous system development; organ morphogenesis; phosphatidylinositol biosynthetic process; phosphoinositide-mediated signaling; positive chemotaxis; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of cardiac muscle cell proliferation; positive regulation of cell division; positive regulation of cell fate specification; positive regulation of cell proliferation; positive regulation of endothelial cell proliferation; positive regulation of MAP kinase activity; positive regulation of phosphoinositide 3-kinase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; Ras protein signal transduction; regulation of angiogenesis; release of sequestered calcium ion into cytosol; signal transduction; small GTPase mediated signal transduction; somatic stem cell maintenance; ureteric bud branching; vascular endothelial growth factor receptor signaling pathway; wound healing
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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