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anti-GABRA1 antibody :: Rabbit GABRA1 Polyclonal Antibody

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Catalog # MBS2518621
Unit / Price
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  0.06 mL  /  $195 +1 FREE 8GB USB
  0.12 mL  /  $270 +1 FREE 8GB USB
  0.2 mL  /  $435 +1 FREE 8GB USB
Testing Data
Product Name

GABRA1, Polyclonal Antibody

Popular Item
Full Product Name

GABRA1 Antibody

Product Synonym Names
ECA4; EJM
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
137160
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
Antigen affinity purification
Immunogen
Fusion protein of GABRA1
Buffer
PBS with 0.1% sodium azide and 50% glycerol pH 7.3
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-7348 / sc-31404 / sc-31405 / sc-31403 / sc-14005
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-GABRA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GABRA1 antibody
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a seperate allosteric effector binding site. Functions as ligand-gated chloride channel.
Applications Tested/Suitable for anti-GABRA1 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-GABRA1 antibody
WB: 1:500-1:5000

Testing Data of anti-GABRA1 antibody
mouse brain tissue were subjected to SDS-PAGE followed by western blot with GABRAI antibody at dilution of l:1000
anti-GABRA1 antibody Testing Data image
NCBI/Uniprot data below describe general gene information for GABRA1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
456aa, 52kDa
NCBI Official Full Name
gamma-aminobutyric acid receptor subunit alpha-1
NCBI Official Synonym Full Names
gamma-aminobutyric acid (GABA) A receptor, alpha 1
NCBI Official Symbol
GABRA1  [Similar Products]
NCBI Official Synonym Symbols
EJM; ECA4; EJM5; EIEE19
  [Similar Products]
NCBI Protein Information
gamma-aminobutyric acid receptor subunit alpha-1; GABA(A) receptor subunit alpha-1; GABA(A) receptor, alpha 1
UniProt Protein Name
Gamma-aminobutyric acid receptor subunit alpha-1
UniProt Synonym Protein Names
GABA(A) receptor subunit alpha-1
UniProt Gene Name
GABRA1  [Similar Products]
UniProt Entry Name
GBRA1_HUMAN
NCBI Summary for GABRA1
This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for GABRA1
GABRA1: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Defects in GABRA1 are the cause of childhood absence epilepsy type 4 (ECA4). A subtype of idiopathic generalized epilepsy characterized by onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. During adolescence, tonic-clonic and myoclonic seizures may develop. Absence seizures may either remit or persist into adulthood. Defects in GABRA1 are the cause of juvenile myoclonic epilepsy type 5 (EJM5). A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, ligand-gated; Transporter; Transporter, ion channel

Chromosomal Location of Human Ortholog: 5q34

Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junction

Molecular Function: chloride channel activity; GABA-A receptor activity; GABA receptor activity; drug binding; extracellular ligand-gated ion channel activity

Biological Process: synaptic transmission; transport; synaptic transmission, GABAergic; transmembrane transport; gamma-aminobutyric acid signaling pathway

Disease: Epilepsy, Idiopathic Generalized, Susceptibility To, 13; Epileptic Encephalopathy, Early Infantile, 19
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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