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anti-GFER antibody :: Rabbit anti-Human, Mouse GFER Polyclonal Antibody

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Catalog # MBS968809
Unit / Price
  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

GFER, Polyclonal Antibody

Popular Item
Also Known As

GFER Antibody

Product Synonym Names
Augmenter of liver regeneration; hERV1; Hepatopoietin; GFER; ALR; HERV1; HPO
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
205
OMIM
600924
3D Structure
ModBase 3D Structure for P55789
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human FAD-linked sulfhydryl oxidase ALR protein(81-205aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-51257
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-GFER antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GFER antibody
Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. Isoform 2: May act as an autocrine hepatotrophic growth factor promoting liver regeneration.
Applications Tested/Suitable for anti-GFER antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-GFER antibody
Recommended dilution: WB:1:200-1000
IHC:1:20-1:200

Western Blot (WB) of anti-GFER antibody
Western blot
All lanes: GFER antibody at 3ug/ml+mouse liver tissue
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 24,16 kDa
Observed band size: 23 kDa

anti-GFER antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-GFER antibody
Immunohistochemistry of paraffin-embedded human testicle using MBS968809 at dilution 1:100
anti-GFER antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-GFER antibody
Immunohistochemistry of paraffin-embedded human colon cancer using MBS968809 at dilution 1:100
anti-GFER antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for GFER. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
15,029 Da
NCBI Official Full Name
FAD-linked sulfhydryl oxidase ALR
NCBI Official Synonym Full Names
growth factor, augmenter of liver regeneration
NCBI Official Symbol
NCBI Official Synonym Symbols
ALR; HPO; HSS; ERV1; HPO1; HPO2; HERV1
  [Similar Products]
NCBI Protein Information
FAD-linked sulfhydryl oxidase ALR
UniProt Protein Name
FAD-linked sulfhydryl oxidase ALR
UniProt Synonym Protein Names
Augmenter of liver regeneration; hERV1; Hepatopoietin
UniProt Gene Name
UniProt Synonym Gene Names
ALR; HERV1; HPO; hERV1  [Similar Products]
UniProt Entry Name
ALR_HUMAN
NCBI Summary for GFER
The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. [provided by RefSeq, Jul 2008]
UniProt Comments for GFER
GFER: Isoform 1: FAD-dependent sulfhydryl oxidase. Within the mitochondrial intermembrane space, participates in a chain of disulfide exchange reactions with MIA40, that generate disulfide bonds in a number of resident proteins with twin Cx3C and Cx9C motifs. Defects in GFER are a cause of mitochondrial progressive myopathy with congenital cataract hearing loss and developmental delay (MPMCHD); also called combined mitochondrial complex deficiency. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Oxidoreductase; EC 1.8.3.2

Chromosomal Location of Human Ortholog: 16p13.3-p13.12

Cellular Component: cytoplasm; extracellular region; mitochondrial intermembrane space; mitochondrion

Molecular Function: FAD binding; growth factor activity; protein binding; protein disulfide oxidoreductase activity; thiol oxidase activity

Biological Process: cellular protein metabolic process; protein targeting to mitochondrion

Disease: Myopathy, Mitochondrial Progressive, With Congenital Cataract, Hearing Loss, And Developmental Delay
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withanti-GFER antibody
 Reference Product  PubMed Publications
 COPS5 antibody  >2 publications with GFER and COPS5
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