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anti-HAX1 antibody :: Rabbit HAX1 Polyclonal Antibody

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Catalog # MBS769997 (SPECIAL PROMOTIONAL PRICING for a limited time)
Unit / Price
  0.1 mg  /  $180 +1 FREE 8GB USB
Product Name

HAX1, Polyclonal Antibody

Popular Item
Full Product Name

HAX1 Rabbit Polyclonal

Product Synonym Names
FLJ17042, FLJ18492, FLJ93803, HAX 1, HAX1, HCLS1 associated protein X 1, HCLSBP1, HS1 associating protein X 1, HS1 binding protein 1, HS1BP1, HSP1BP 1, SCN3
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
605998
3D Structure
ModBase 3D Structure for O00165
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Specificity
Human, Mouse; other species are not tested. Please decide the specificity by homology
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Form/Format
Liquid
Immunogen
HCLS1 associated protein X-1
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.3
Preparation and Storage
-20 degree C for 24 months (Avoid repeated freeze/thaw cycles.)
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-HAX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-HAX1 antibody
HAX1, also named as HS1BP1, is a 32 kDa protein that is ubiquitously expressed. Hax1 has beendemonstrated to be a negative regulator of apoptosis in many immune cell types. Furthermore, Hax1has been shown to have additional roles in regulating cell motility and adhesion, and isoverexpressed in many types of cancer. Kristina and Cavnar demonstrate in their paper validation oftwo research antibodies including ProteintechÂ’s anti-Hax1 (11266-1-AP). They have evidence thatthe rabbit anti-Hax1 (11266-1-AP, Proteintech Group Inc.) results in a more robust and consistentdetection of Hax1.
Applications Tested/Suitable for anti-HAX1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
Application Notes for anti-HAX1 antibody
WB : 1:200-1:1000
IP : 1:200-1:1000
IHC : 1:20-1:200

Immunohistochemistry of anti-HAX1 antibody
Immunohistochemistry of paraffin-embedded human lymphoma using MBS769997 (HAX1 antibody) at dilution of 1:50
anti-HAX1 antibody Immunohistochemistry (IHC) image
IP Result of anti-HAX1 (IP: MBS769997, 3ug; Detection: MBS769997 (1:300) with mouse brain tissue lysate 6000ug.
anti-HAX1 antibody IP image
SDS-PAGE of anti-HAX1 antibody
HeLa cells were subjected to SDS PAGE followed by western blot with MBS769997 (HAX1 Antibody) at dilution of 1:300
anti-HAX1 antibody SDS-PAGE image
NCBI/Uniprot data below describe general gene information for HAX1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
32 kDa
NCBI Official Full Name
HCLS1-associated protein X-1 isoform b
NCBI Official Synonym Full Names
HCLS1 associated protein X-1
NCBI Official Symbol
NCBI Official Synonym Symbols
SCN3; HS1BP1; HCLSBP1
  [Similar Products]
NCBI Protein Information
HCLS1-associated protein X-1
UniProt Protein Name
HCLS1-associated protein X-1
UniProt Synonym Protein Names
HS1-associating protein X-1; HAX-1; HS1-binding protein 1; HSP1BP-1
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
HS1BP1; HAX-1; HSP1BP-1  [Similar Products]
UniProt Entry Name
HAX1_HUMAN
NCBI Summary for HAX1
The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for HAX1
HAX1: Promotes cell survival. Potentiates GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. May regulate intracellular calcium pools. Defects in HAX1 are the cause of neutropenia severe congenital autosomal recessive type 3 (SCN3); also known as Kostmann disease. A disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections. Some patients affected by severe congenital neutropenia type 3 have neurological manifestations such as psychomotor retardation and seizures. The clinical phenotype due to HAX1 deficiency appears to depend on the localization of the mutations and their influence on the transcript variants. Mutations affecting exclusively isoform 1 are associated with isolated congenital neutropenia, whereas mutations affecting both isoform 1 and isoform 5 are associated with additional neurologic symptoms. Belongs to the HAX1 family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Endoplasmic reticulum; Vesicle; Mitochondrial

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: actin cytoskeleton; cytoplasmic membrane-bound vesicle; endoplasmic reticulum; lamellipodium; mitochondrial intermembrane space; mitochondrial outer membrane; mitochondrion; nuclear envelope; nuclear membrane; sarcoplasmic reticulum; transcription factor complex

Molecular Function: interleukin-1 binding; protein binding; protein N-terminus binding

Biological Process: mitochondrion organization and biogenesis; negative regulation of apoptosis; positive regulation of granulocyte differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of transcription from RNA polymerase II promoter; regulation of actin filament polymerization; regulation of apoptosis

Disease: Neutropenia, Severe Congenital, 3, Autosomal Recessive
Precautions
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Disclaimer
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