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anti-HLA-A antibody :: Rabbit HLA class I (HLA-A) Polyclonal Antibody

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Catalog # MBS7600128
Unit / Price
  0.1 mg  /  $320 +1 FREE 8GB USB
Product Name

HLA class I (HLA-A), Polyclonal Antibody

Popular Item
Also Known As

HLA class I (HLA-A) Rabbit Polyclonal

Product Synonym Names
HLA A, HLAA, HLA-A
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS7600128 Technical Datasheet
Immunogen Sequence Length
365
OMIM
142800
3D Structure
ModBase 3D Structure for P04439
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human; Mouse; other species are not tested.
Specificity
Please decide specifity by homology.
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Form/Format
Liquid
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Immunogen
Major histocompatibility complex, class I, A
Calculated MW
44 kDa
Preparation and Storage
-20°C for 24 months (Avoid repeated freeze / thaw cycles.)
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-HLA-A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-HLA-A antibody
ELISA, WB, IHC.
Application Notes for anti-HLA-A antibody
WB: 1:500-1:2000
IHC: 1:50-1:200

Immunohistochemistry IHC of anti-HLA-A antibody
Immunohistochemistry of paraffin-embedded human esophagus using MBS7600128 (HLA class (HLA-A antibody) at dilution of 1:100
anti-HLA-A antibody Immunohistochemistry IHC (IHC) image
Western Blot WB of anti-HLA-A antibody
HepG2 cells were subjected to SDS PAGE followed by western blot with MBS7600128(HLA class I(HLA-A antibody) at dilution of 1:1000
anti-HLA-A antibody Western Blot WB (WB) image
NCBI/Uniprot data below describe general gene information for HLA-A. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
HLA class I histocompatibility antigen, A-1 alpha chain
NCBI Official Synonym Full Names
major histocompatibility complex, class I, A
NCBI Official Symbol
HLA-A  [Similar Products]
NCBI Official Synonym Symbols
HLAA; Aw-33; Aw-74; HLA-A11; HLA-A33; HLA-DQB1; HLA-DRB1
  [Similar Products]
NCBI Protein Information
HLA class I histocompatibility antigen, A-1 alpha chain
UniProt Protein Name
HLA class I histocompatibility antigen, A-2 alpha chain
UniProt Synonym Protein Names
MHC class I antigen A*2
UniProt Gene Name
HLA-A  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
1A02_HUMAN
NCBI Summary for HLA-A
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for HLA-A
HLAA: Involved in the presentation of foreign antigens to the immune system. Belongs to the MHC class I family.

Protein type: Membrane protein, integral; Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: cell surface; early endosome membrane; endoplasmic reticulum; Golgi apparatus; Golgi medial cisterna; Golgi membrane; integral to plasma membrane; membrane; MHC class I protein complex; phagocytic vesicle membrane; plasma membrane

Molecular Function: beta-2-microglobulin binding; peptide antigen binding; protein binding; receptor binding; T cell receptor binding; TAP binding

Biological Process: antibacterial humoral response; antigen processing and presentation; antigen processing and presentation of endogenous peptide antigen via MHC class I; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; antigen processing and presentation of peptide antigen via MHC class I; defense response to Gram-positive bacterium; detection of bacterium; immune response; positive regulation of interferon-gamma production; positive regulation of T cell cytokine production; positive regulation of T cell mediated cytotoxicity; protection from natural killer cell mediated cytotoxicity; regulation of defense response to virus by virus; regulation of immune response; viral reproduction

Disease: Severe Cutaneous Adverse Reaction, Susceptibility To
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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