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anti-HS2ST1 antibody :: Rabbit anti-Human, Mouse HS2ST1 Polyclonal Antibody

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Catalog # MBS1491783
Unit / Price
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  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

HS2ST1, Polyclonal Antibody

Popular Item
Full Product Name

HS2ST1 Antibody

Product Synonym Names
Heparan sulfate 2-O-sulfotransferase 1 (EC:2.8.2.-); 2-O-sulfotransferase; 2OST; HS2ST1; HS2ST; KIAA0448
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
604844
3D Structure
ModBase 3D Structure for Q7LGA3
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
>95%, Protein G Purified
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
Non-conjugated
Immunogen
Recombinant human Heparan sulfate 2-O-sulfotransferase 1 protein
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-103549 / sc-130779 / sc-292203
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-HS2ST1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-HS2ST1 antibody
Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity).
Applications Tested/Suitable for anti-HS2ST1 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-HS2ST1 antibody
Recommended dilution: WB:1:500-2000

Western Blot (WB) of anti-HS2ST1 antibody
Western blot
All lanes: HS2ST1 antibody at 6ug/ml
Lane 1:mouse skeletal muscle tissue
Lane 2:mouse heart tissue
Lane 3:PC-3 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 42,35,27 kDa
Observed band size: 42 kDa

anti-HS2ST1 antibody Western Blot (WB) (WB) image
Western Blot (WB) of anti-HS2ST1 antibody
Western Blot
Positive WB detected in: Rat spleen tissue
All lanes: HS2ST1 antibody at 2.7ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 42,35,27 KDa
Observed band size: 42 KDa

anti-HS2ST1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-HS2ST1 antibody
Immunohistochemistry of paraffin-embedded human pancreatic tissue using MBS1491783 at dilution of 1:100
anti-HS2ST1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-HS2ST1 antibody
Immunohistochemistry of paraffin-embedded human lung cancer using MBS1491783 at dilution of 1:100
anti-HS2ST1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for HS2ST1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,757 Da
NCBI Official Full Name
heparan sulfate 2-O-sulfotransferase 1 isoform 2
NCBI Official Synonym Full Names
heparan sulfate 2-O-sulfotransferase 1
NCBI Official Symbol
HS2ST1  [Similar Products]
NCBI Official Synonym Symbols
dJ604K5.2
  [Similar Products]
NCBI Protein Information
heparan sulfate 2-O-sulfotransferase 1
UniProt Protein Name
Heparan sulfate 2-O-sulfotransferase 1
UniProt Gene Name
HS2ST1  [Similar Products]
UniProt Synonym Gene Names
HS2ST; KIAA0448; 2-O-sulfotransferase; 2OST  [Similar Products]
UniProt Entry Name
HS2ST_HUMAN
NCBI Summary for HS2ST1
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes a member of the heparan sulfate biosynthetic enzyme family that transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation. Two alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Aug 2008]
UniProt Comments for HS2ST1
HS2ST1: Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high- affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues. Belongs to the sulfotransferase 3 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Glycan Metabolism - heparan sulfate biosynthesis; Transferase; EC 2.8.2.-; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p22.3

Cellular Component: Golgi membrane; integral to membrane; membrane

Molecular Function: sulfotransferase activity

Biological Process: carbohydrate metabolic process; glycosaminoglycan biosynthetic process; glycosaminoglycan metabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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