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anti-ICOS antibody :: Goat ICOS Polyclonal Antibody

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Catalog # MBS421835
Unit / Price
  0.1 mg  /  $300 +1 FREE 8GB USB
anti-ICOS antibody
Product Name

ICOS, Polyclonal Antibody

Also Known As

Goat anti-ICOS Antibody

Product Synonym Names
ICOS; inducible T-cell co-stimulator; AILIM; CD278; MGC39850; activation-inducible lymphocyte immunomediatory molecule; inducible costimulator; ICOS antibody; inducible T-cell co-stimulator antibody; AILIM antibody; CD278 antibody; MGC39850 antibody; activation-inducible lymphocyte immunomediatory molecule antibody; inducible costimulator antibody
Antibody/Peptide Pairs
ICOS peptide (MBS426984) is used for blocking the activity of ICOS antibody (MBS421835)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
199
Immunogen Sequence
KGGQILCDLT KTKGS
OMIM
604558
Clonality
Polyclonal
Host
Goat
Species Reactivity
Expected from sequence similarity: Human, Mouse
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence KGGQILCDLTKTKGS, from the internal region of the protein sequence according to NP_036224.1.
Epitope
Internal region
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-ICOS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ICOS antibody
Peptide ELISA (EIA)
Application Notes for anti-ICOS antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Preliminary experiments gave an approx 13kDa band in Human Peripheral Blood Lymphocyte lysates after 0. 01ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 22.6kDa according to NP_036224.1. The 13kDa band was successfully blocked by incubation with the immunizing peptide.
NCBI/Uniprot data below describe general gene information for ICOS. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
19,127 Da
NCBI Official Full Name
inducible T-cell costimulator
NCBI Official Synonym Full Names
inducible T-cell co-stimulator
NCBI Official Symbol
NCBI Official Synonym Symbols
AILIM; CD278; CVID1
  [Similar Products]
NCBI Protein Information
inducible T-cell costimulator
UniProt Protein Name
Inducible T-cell costimulator
UniProt Synonym Protein Names
Activation-inducible lymphocyte immunomediatory molecule; CD_antigen: CD278
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
AILIM  [Similar Products]
UniProt Entry Name
ICOS_HUMAN
NCBI Summary for ICOS
The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]
UniProt Comments for ICOS
ICOS: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes. Defects in ICOS are the cause of immunodeficiency common variable type 1 (CVID1). CVID1 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be lo. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q33

Cellular Component: external side of plasma membrane; extracellular region; integral to plasma membrane; plasma membrane

Biological Process: cell-cell adhesion; immune response; T cell costimulation; T cell tolerance induction

Disease: Immunodeficiency, Common Variable, 1; Immunodeficiency, Common Variable, 2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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