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anti-IFNLR1 antibody :: Rabbit anti-Human, Mouse IFNLR1 Polyclonal Antibody

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Catalog # MBS7045831
Unit / Price
  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

IFNLR1, Polyclonal Antibody

Popular Item
Full Product Name

IFNLR1 Antibody

Product Synonym Names
Interferon lambda receptor 1; IFN-lambda receptor 1; IFN-lambda-R1; Cytokine receptor class-II member 12; Cytokine receptor family 2 member 12; CRF2-12; Interleukin-28 receptor subunit alpha; IL-28 receptor subunit alpha; IL-28R-alpha; IL-28RA; Likely interleukin or cytokine receptor 2; LICR2; IFNLR1; IL28RA; LICR2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS7045831 Technical Datasheet
OMIM
607404
3D Structure
ModBase 3D Structure for Q8IU57
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
Antigen Affinity Purified
Form/Format
Liquid; PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Species
Human
Immunogen
Recombinant human Interferon lambda receptor 1 protein (21-228AA)
Research Area
Immunology
Conjugate
Non-conjugated
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-66541 / sc-66542 / sc-135101
Preparation and Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-IFNLR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IFNLR1 antibody
The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.
Applications Tested/Suitable for anti-IFNLR1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-IFNLR1 antibody
WB 1:1000-1:5000
IHC 1:20-1:200

Western Blot (WB) of anti-IFNLR1 antibody
Western blot
All lanes: IFNLR1antibody at 3.04ug/ml
Lane 1: Mouse kidney tissue
Lane 2: Mouse liver tissue
Lane 3: Human placenta tissue
Lane 4: Mouse lung tissue
Lane 5: Jurkat whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 58,55,24,28 kDa
Observed band size: 58 kDa

anti-IFNLR1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-IFNLR1 antibody
Immunohistochemistry of paraffin-embedded human testis tissue MBS7045831 at dilution 1:100
anti-IFNLR1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-IFNLR1 antibody
Immunohistochemistry of paraffin-embedded human adrenal gland tissue MBS7045831 at dilution 1:100
anti-IFNLR1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for IFNLR1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
interferon lambda receptor 1 isoform 1
NCBI Official Synonym Full Names
interferon lambda receptor 1
NCBI Official Symbol
IFNLR1  [Similar Products]
NCBI Official Synonym Symbols
IFNLR; LICR2; IL28RA; CRF2/12; IL-28R1
  [Similar Products]
NCBI Protein Information
interferon lambda receptor 1
UniProt Protein Name
Interferon lambda receptor 1
UniProt Synonym Protein Names
Cytokine receptor class-II member 12; Cytokine receptor family 2 member 12; CRF2-12; Interleukin-28 receptor subunit alpha; IL-28 receptor subunit alpha; IL-28R-alpha; IL-28RA; Likely interleukin or cytokine receptor 2; LICR2
UniProt Gene Name
IFNLR1  [Similar Products]
UniProt Synonym Gene Names
IL28RA; LICR2; IFN-lambda receptor 1; IFN-lambda-R1; CRF2-12; IL-28 receptor subunit alpha; IL-28R-alpha; IL-28RA; LICR2  [Similar Products]
UniProt Entry Name
INLR1_HUMAN
NCBI Summary for IFNLR1
The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
UniProt Comments for IFNLR1
IL28RA: The IL28RA/IL10RB dimer is a receptor for IL28A, IL28B and IL29. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the type II cytokine receptor family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: interleukin-28 receptor complex; plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding

Biological Process: cytokine and chemokine mediated signaling pathway; defense response to virus; mucosal immune response; regulation of defense response to virus by host
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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