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anti-IL-21 antibody :: Rabbit anti-Human, Mouse IL-21 Polyclonal Antibody

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Catalog # MBS2538457
Unit / Price
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  0.02 mL  /  $110 +1 FREE 8GB USB
  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Western Blot (WB)
Product Name

IL-21, Polyclonal Antibody

Popular Item
Full Product Name

IL-21 Polyclonal Antibody

Product Synonym Names
IL21; Interleukin-21; IL-21; Za11
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
605384
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
Antigen Affinity Purified
Concentration
1 mg/ml (lot specific)
Immunogen
Synthesized peptide derived from the Internal region of human IL-21.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-IL-21 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-IL-21 antibody
Applications Tested/Suitable for anti-IL-21 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-IL-21 antibody
WB: 1:500-1:2000, ELISA: 1:5000-1:20000

Western Blot (WB) of anti-IL-21 antibody
Western Blot analysis of various cells using IL-21 Polyclonal Antibody at dilution of 1:500.
anti-IL-21 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for IL-21. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 18
Observed MW: 18
NCBI Official Full Name
interleukin-21 isoform 2
NCBI Official Synonym Full Names
interleukin 21
NCBI Official Symbol
NCBI Official Synonym Symbols
Za11; IL-21; CVID11
  [Similar Products]
NCBI Protein Information
interleukin-21
UniProt Protein Name
Interleukin-21
UniProt Synonym Protein Names
Za11
UniProt Gene Name
UniProt Synonym Gene Names
IL-21  [Similar Products]
UniProt Entry Name
IL21_HUMAN
NCBI Summary for IL-21
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
UniProt Comments for IL-21
IL21: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. Belongs to the IL-15/IL-21 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Cell development/differentiation; Cytokine; Apoptosis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q26-q27

Cellular Component: extracellular space; intracellular

Molecular Function: cytokine activity; hematopoietin/interferon-class (D200-domain) cytokine receptor binding; interleukin-2 receptor binding

Biological Process: cell maturation; immune response; positive regulation of B cell proliferation; positive regulation of cell proliferation; positive regulation of cytokine production; positive regulation of inflammatory response; positive regulation of interferon-gamma biosynthetic process; positive regulation of interleukin-10 production; positive regulation of interleukin-17 production; positive regulation of natural killer cell cytokine production; positive regulation of natural killer cell differentiation; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of T cell proliferation; positive regulation of tissue remodeling; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of tyrosine phosphorylation of Stat3 protein; signal transduction; tyrosine phosphorylation of Stat3 protein

Disease: Immunodeficiency, Common Variable, 11
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-IL-21 antibody
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