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anti-ITGA6 antibody :: Rabbit anti-Human, Mouse ITGA6 Polyclonal Antibody

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Catalog # MBS9403415
Unit / Price
  0.1 mL  /  $255 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

ITGA6, Polyclonal Antibody

Popular Item
Also Known As

ITGA6 Antibody

Product Synonym Names
CD49f; VLA-6; ITGA6B
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
1073
OMIM
147556
3D Structure
ModBase 3D Structure for P23229
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Specificity
The antibody detects endogenous levels of total ITGA6 protein.
Purity/Purification
Antigen affinity purification.
Form/Format
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Concentration
1.7 mg/ml (lot specific)
Immunogen Type
Peptide
Immunogen Description
Synthetic peptide corresponding to a region derived from internal residues of human integrin, alpha 6
Target Name
ITGA6
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-ITGA6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ITGA6 antibody
The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.
Product Categories/Family for anti-ITGA6 antibody
Applications Tested/Suitable for anti-ITGA6 antibody
Immunohistochemistry (IHC)
Application Notes for anti-ITGA6 antibody
Immunohistochemistry: 1:25-1:100

Immunohistochemistry (IHC) of anti-ITGA6 antibody
Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using at dilution 1/50.
anti-ITGA6 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for ITGA6. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
122,358 Da
NCBI Official Full Name
integrin alpha-6 isoform b
NCBI Official Synonym Full Names
integrin, alpha 6
NCBI Official Symbol
ITGA6  [Similar Products]
NCBI Official Synonym Symbols
CD49f; VLA-6; ITGA6B
  [Similar Products]
NCBI Protein Information
integrin alpha-6
UniProt Protein Name
Integrin alpha-6
UniProt Synonym Protein Names
CD49 antigen-like family member F; VLA-6; CD_antigen: CD49f
Protein Family
UniProt Gene Name
ITGA6  [Similar Products]
UniProt Synonym Gene Names
Alpha6p  [Similar Products]
UniProt Entry Name
ITA6_HUMAN
NCBI Summary for ITGA6
The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ITGA6
ITGA6: Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4. Interacts with HPS5. Interacts with RAB21. Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney). Belongs to the integrin alpha chain family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis; Receptor, misc.

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: cell surface; cell-cell adherens junction; focal adhesion; hemidesmosome; basal plasma membrane; plasma membrane; basement membrane; filopodium; external side of plasma membrane

Molecular Function: integrin binding; protein binding; metal ion binding; laminin binding

Biological Process: skin development; integrin-mediated signaling pathway; extracellular matrix organization and biogenesis; filopodium formation; positive regulation of apoptosis; cell-matrix adhesion; cell-substrate adhesion; hemidesmosome assembly; cell-cell adhesion; gut development; positive regulation of cell-cell adhesion; cell-substrate junction assembly; brown fat cell differentiation; cellular response to extracellular stimulus; cell adhesion mediated by integrin; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; leukocyte migration; positive regulation of phosphorylation

Disease: Epidermolysis Bullosa Junctionalis With Pyloric Atresia
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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