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anti-KDM6B antibody :: Rabbit anti-Human, Mouse JMJD3 Polyclonal Antibody

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Catalog # MBS647954
Unit / Price
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  0.2 mL  /  $610 +1 FREE 8GB USB
anti-KDM6B antibody
Product Name

JMJD3 (KDM6B), Polyclonal Antibody

Full Product Name

JMJD3, ID (Kdm6b, Jmjd3, Kiaa0346, Lysine-specific demethylase 6B, JmjC domain-containing protein 3, Jumonji domain-containing protein 3)

Product Synonym Names
Anti -JMJD3, ID (Kdm6b, Jmjd3, Kiaa0346, Lysine-specific demethylase 6B, JmjC domain-containing protein 3, Jumonji domain-containing protein 3)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 17; NC_000017.10 (7737521..7758118). Location: 17p13.1
OMIM
611577
3D Structure
ModBase 3D Structure for O15054
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Specificity
Human, mouse
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Immunogen
Mouse JMJD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 964~993 amino acids from the center region of mouse JMJD3.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-KDM6B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KDM6B antibody
Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
Product Categories/Family for anti-KDM6B antibody
Applications Tested/Suitable for anti-KDM6B antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-KDM6B antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:50-100
NCBI/Uniprot data below describe general gene information for KDM6B. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
176,632 Da[Similar Products]
NCBI Official Full Name
JMJD3 protein
NCBI Official Synonym Full Names
lysine (K)-specific demethylase 6B
NCBI Official Symbol
KDM6B  [Similar Products]
NCBI Official Synonym Symbols
JMJD3
  [Similar Products]
NCBI Protein Information
lysine-specific demethylase 6B; lysine demethylase 6B; jmjC domain-containing protein 3; jumonji domain-containing protein 3; jumonji domain containing 3, histone lysine demethylase
UniProt Protein Name
Lysine-specific demethylase 6B
UniProt Synonym Protein Names
JmjC domain-containing protein 3; Jumonji domain-containing protein 3; Lysine demethylase 6B
UniProt Gene Name
KDM6B  [Similar Products]
UniProt Synonym Gene Names
JMJD3; KIAA0346  [Similar Products]
UniProt Entry Name
KDM6B_HUMAN
UniProt Comments for KDM6B
Function: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Ref.6 Ref.7

Cofactor: Ascorbate

By similarity. Ref.6Fe2+. Ref.6

Subunit structure: Interacts with TLE1

By similarity. Component of the MLL4 complex, at least composed of KMT2B/MLL4, ASH2L, RBBP5, WDR5, and KDM6B. Ref.6

Subcellular location: Nucleus

Probable Ref.6.

Induction: By 12-O-tetradecanoylphorbol-13-acetate (TPA) in myeloid leukemia cells. Ref.5

Sequence similarities: Belongs to the UTX family.Contains 1 JmjC domain.

Sequence caution: The sequence BAA21572.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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