Q8N371.1
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Lysine-specific demethylase 8
NCBI Official Synonym Full Names
lysine demethylase 8
NCBI Official Synonym Symbols
NCBI Protein Information
lysine-specific demethylase 8
UniProt Protein Name
Lysine-specific demethylase 8
UniProt Synonym Protein Names
JmjC domain-containing protein 5; Jumonji domain-containing protein 5
UniProt Synonym Gene Names
NCBI Summary for KDM8
This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009]
UniProt Comments for KDM8
JMJD5: Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation; Demethylase; EC 1.14.11.27
Chromosomal Location of Human Ortholog: 16p12.1
Cellular Component: cytosol; nucleoplasm; nucleus
Molecular Function: chromatin binding; histone demethylase activity; histone demethylase activity (H3-K36 specific)
Biological Process: G2/M transition of mitotic cell cycle; positive regulation of transcription, DNA-dependent
Research Articles on KDM8
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-KDM8 antibody
Diseases associated with anti-KDM8 antibody
Organs/Tissues associated with anti-KDM8 antibody
|