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anti-KPNA4 antibody :: Rabbit anti-Human, Mouse KPNA4 Polyclonal Antibody

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Catalog # MBS7048540
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

KPNA4, Polyclonal Antibody

Popular Item
Also Known As

KPNA4 Antibody

Product Synonym Names
Importin subunit alpha-3; Importin alpha Q1; Qip1; Karyopherin subunit alpha-4; KPNA4; QIP1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
521
OMIM
AB002533 mRNA
3D Structure
ModBase 3D Structure for O00629
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Immunogen
Recombinant Human Importin subunit alpha-3 protein (51-239AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, PH 7.4
Conjugation
Non-conjugated
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-55266 / sc-55267 / sc-55270
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-KPNA4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KPNA4 antibody
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
Applications Tested/Suitable for anti-KPNA4 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-KPNA4 antibody
WB: 1: 500-1: 5000
IHC: 1: 20-1: 200
IF: 1: 50-1: 200

Western Blot (WB) of anti-KPNA4 antibody
Western Blot
Positive WB detected in:Mouse heart tissue,Mouse lung tissue,Mouse brain tissue,Mouse kidney tissue,Mouse skeletal muscle tissue
All lanes: KPNA4 antibody at 3.5ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 58 kDa
Observed band size: 58 kDa

anti-KPNA4 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-KPNA4 antibody
Immunohistochemistry of paraffin-embedded human testis tissue using MBS7048540 at dilution of 1:100
anti-KPNA4 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-KPNA4 antibody
Immunohistochemistry of paraffin-embedded human prostate cancer using MBS7048540 at dilution of 1:100
anti-KPNA4 antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-KPNA4 antibody
Immunofluorescent analysis of PC3 cells using MBS7048540 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-KPNA4 antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for KPNA4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,887 Da
NCBI Official Full Name
importin subunit alpha-3
NCBI Official Synonym Full Names
karyopherin subunit alpha 4
NCBI Official Symbol
KPNA4  [Similar Products]
NCBI Official Synonym Symbols
QIP1; SRP3; IPOA3
  [Similar Products]
NCBI Protein Information
importin subunit alpha-3
UniProt Protein Name
Importin subunit alpha-3
UniProt Synonym Protein Names
Importin alpha Q1; Qip1; Karyopherin subunit alpha-4
UniProt Gene Name
KPNA4  [Similar Products]
UniProt Synonym Gene Names
QIP1; Qip1  [Similar Products]
UniProt Entry Name
IMA3_HUMAN
NCBI Summary for KPNA4
The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. [provided by RefSeq, Jul 2008]
UniProt Comments for KPNA4
KPNA4: an alpha importin protein that functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Forms a complex with importin beta-1 subunit.

Protein type: Adaptor/scaffold; Chaperone; Karyopherin; Nuclear import

Chromosomal Location of Human Ortholog: 3q25.33

Cellular Component: cytosol; nuclear pore; nucleoplasm

Molecular Function: nuclear localization sequence binding; protein binding; protein transporter activity

Biological Process: modification by virus of host cellular process; NLS-bearing substrate import into nucleus
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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