• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-LBR antibody :: Rabbit anti-Human, Mouse Lamin B Receptor Polyclonal Antibody

Scan QR to view Datasheet
Catalog # MBS8245721
Unit / Price
Scan QR to view Datasheet
  0.05 mL  /  $195 +1 FREE 8GB USB
  0.1 mL  /  $250 +1 FREE 8GB USB
  0.2 mL  /  $350 +1 FREE 8GB USB
Product Name

Lamin B Receptor (LBR), Polyclonal Antibody

Full Product Name

Anti-Lamin B Receptor Antibody

Product Synonym Names
Lamin-B receptor; Integral nuclear envelope inner membrane protein; LMN2R
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
169400
3D Structure
ModBase 3D Structure for Q14739
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Specificity
Recognizes endogenous levels of Lamin B Receptor protein.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
Recombinant full length protein of human Lamin B Receptor
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-LBR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LBR antibody
Rabbit polyclonal antibody to Lamin B Receptor
Applications Tested/Suitable for anti-LBR antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-LBR antibody
WB: 1/500 - 1/2000; IHC: 1/50 - 1/200

Western Blot (WB) of anti-LBR antibody
Western blot analysis of Lamin B Receptor expression in K562 (A), HT29 (B), mouse spleen (C), mouse lung (D) whole cell lysates.
anti-LBR antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-LBR antibody
Immunohistochemical analysis of Lamin B Receptor staining in rat brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
anti-LBR antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for LBR. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
70,703 Da
NCBI Official Full Name
lamin-B receptor
NCBI Official Synonym Full Names
lamin B receptor
NCBI Official Symbol
NCBI Official Synonym Symbols
PHA; LMN2R; TDRD18; DHCR14B
  [Similar Products]
NCBI Protein Information
lamin-B receptor
UniProt Protein Name
Lamin-B receptor
UniProt Synonym Protein Names
Integral nuclear envelope inner membrane protein; LMN2R
Protein Family
UniProt Gene Name
UniProt Entry Name
LBR_HUMAN
NCBI Summary for LBR
The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for LBR
LBR: Anchors the lamina and the heterochromatin to the inner nuclear membrane. Defects in LBR are a cause of Pelger-Huet anomaly (PHA). PHA is an autosomal dominant inherited abnormality of neutrophils, characterized by reduced nuclear segmentation and an apparently looser chromatin structure. Heterozygotes show hypolobulated neutrophil nuclei with coarse chromatin. Presumed homozygous individuals have ovoid neutrophil nuclei, as well as varying degrees of developmental delay, epilepsy, and skeletal abnormalities. Defects in LBR are the cause of hydrops-ectopic calcification-moth-eaten skeletal dysplasia (HEM); also known as Greenberg skeletal dysplasia. HEM is a rare autosomal recessive chondrodystrophy characterized by early in utero lethality and, therefore, considered to be nonviable. Affected fetuses typically present with fetal hydrops, short- limbed dwarfism, and a marked disorganization of chondro-osseous calcification and may present with polydactyly and additional nonskeletal malformations. Defects in LBR may be a cause of Reynolds syndrome (REYNS). It is a syndrome specifically associating limited cutaneous systemic sclerosis and primary biliray cirrhosis. It is characterized by liver disease, telangiectasia, abrupt onset of digital paleness or cyanosis in response to cold exposure or stress (Raynaud phenomenon), and variable features of scleroderma. The liver disease is characterized by pruritis, jaundice, hepatomegaly, increased serum alkaline phosphatase and positive serum mitochondrial autoantibodies, all consistent with primary biliary cirrhosis. Belongs to the ERG4/ERG24 family.

Protein type: Membrane protein, multi-pass; DNA-binding; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q42.1

Cellular Component: integral to endoplasmic reticulum membrane; integral to membrane; integral to nuclear inner membrane; membrane; nuclear envelope; nuclear membrane

Molecular Function: delta14-sterol reductase activity; DNA binding; lamin binding; oxidoreductase activity, acting on the CH-CH group of donors; protein binding

Biological Process: cholesterol biosynthetic process; sterol biosynthetic process

Disease: Greenberg Dysplasia; Pelger-huet Anomaly; Reynolds Syndrome
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000