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anti-LAMC3 antibody :: Rabbit anti-Human, Mouse Laminin gamma-3 Polyclonal Antibody

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Catalog # MBS2539366
Unit / Price
  0.02 mL  /  $110 +1 FREE 8GB USB
  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Western Blot (WB)
Product Name

Laminin gamma-3 (LAMC3), Polyclonal Antibody

Popular Item
Full Product Name

Laminin gamma-3 Polyclonal Antibody

Product Synonym Names
LAMC3; Laminin subunit gamma-3; Laminin-12 subunit gamma; Laminin-14 subunit gamma; Laminin-15 subunit gamma
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
604349
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
Antigen Affinity Purified
Concentration
1 mg/ml (lot specific)
Immunogen
Synthesized peptide derived from the C-terminal region of human Laminin gamma-3.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-LAMC3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-LAMC3 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-LAMC3 antibody
WB: 1:500-1:2000, IHC: 1:50-1:200, IF: 1:50-1:100, ELISA: 1:5000-1:20000

Western Blot (WB) of anti-LAMC3 antibody
Western Blot analysis of SH-SY5Y cells using Laminin ?-3 Polyclonal Antibody at dilution of 1:1000.
anti-LAMC3 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for LAMC3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 172
Observed MW: 170[Similar Products]
NCBI Official Full Name
laminin subunit gamma-3
NCBI Official Synonym Full Names
laminin subunit gamma 3
NCBI Official Symbol
LAMC3  [Similar Products]
NCBI Official Synonym Symbols
NCBI Protein Information
laminin subunit gamma-3
UniProt Protein Name
Laminin subunit gamma-3
UniProt Synonym Protein Names
Laminin-12 subunit gamma; Laminin-14 subunit gamma; Laminin-15 subunit gamma
Protein Family
UniProt Gene Name
LAMC3  [Similar Products]
UniProt Entry Name
LAMC3_HUMAN
NCBI Summary for LAMC3
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 3. The gamma 3 chain is most similar to the gamma 1 chain, and contains all the 6 domains expected of the gamma chain. It is a component of laminin 12. The gamma 3 chain is broadly expressed in skin, heart, lung, and the reproductive tracts. In skin, it is seen within the basement membrane of the dermal-epidermal junction at points of nerve penetration. Gamma 3 is also a prominent element of the apical surface of ciliated epithelial cells of lung, oviduct, epididymis, ductus deferens, and seminiferous tubules. The distribution of gamma 3-containing laminins along ciliated epithelial surfaces suggests that the apical laminins are important in the morphogenesis and structural stability of the ciliated processes of these cells. [provided by RefSeq, Aug 2011]
UniProt Comments for LAMC3
LAMC3: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Defects in LAMC3 are the cause of cortical malformations occipital (OCCM). OCCM is a disease in which affected individuals develop seizures, sometimes associated with transient visual changes. Brain MRI shows both pachygyria and polymicrogyria restricted to the lateral occipital lobes.

Protein type: Motility/polarity/chemotaxis; Extracellular matrix; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 9q34.12

Cellular Component: basement membrane; extracellular region; membrane; proteinaceous extracellular matrix

Molecular Function: structural molecule activity

Biological Process: astrocyte development; cell adhesion; cellular morphogenesis during differentiation; extracellular matrix organization and biogenesis; retina development in camera-type eye; visual perception

Disease: Cortical Malformations, Occipital
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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