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anti-MAPT antibody :: Rabbit anti-Human, Mouse MAPT Polyclonal Antibody

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Catalog # MBS7049571
Unit / Price
Scan QR to view Datasheet
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

MAPT, Polyclonal Antibody

Popular Item
Full Product Name

MAPT Antibody

Product Synonym Names
Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; MAPT; MAPTL; MTBT1; TAU
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
J03778 mRNA
3D Structure
ModBase 3D Structure for P10636
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Immunogen
Recombinant human Microtubule-associated protein tau protein (33-166AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, PH 7.4
Conjugation
Non-conjugated
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-1995 / sc-1996 / sc-5587
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-MAPT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MAPT antibody
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Applications Tested/Suitable for anti-MAPT antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-MAPT antibody
WB: 1: 1000-1: 5000
IHC: 1: 20-1: 200
IF: 1: 50-1: 200

Western Blot (WB) of anti-MAPT antibody
Western Blot
Positive WB detected in:SH-SY5Y whole cell lysate,Mouse heart tissue
All lanes: MAPT antibody at 3.25ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 79,37,33,40,43,41,46,81 kDa
Observed band size: 79,50,36 kDa

anti-MAPT antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-MAPT antibody
Immunohistochemistry of paraffin-embedded human brain tissue using MBS7049571 at dilution of 1:100
anti-MAPT antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-MAPT antibody
Immunofluorescent analysis of HepG2 cells using MBS7049571 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-MAPT antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for MAPT. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
80,941 Da
NCBI Official Full Name
microtubule-associated protein tau isoform 6
NCBI Official Synonym Full Names
microtubule associated protein tau
NCBI Official Symbol
NCBI Official Synonym Symbols
TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103
  [Similar Products]
NCBI Protein Information
microtubule-associated protein tau
UniProt Protein Name
Microtubule-associated protein tau
UniProt Synonym Protein Names
Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau
UniProt Gene Name
UniProt Synonym Gene Names
MAPTL; MTBT1; TAU; PHF-tau  [Similar Products]
UniProt Entry Name
TAU_HUMAN
NCBI Summary for MAPT
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
UniProt Comments for MAPT
Tau: a microtubule-associated protein that regulates microtubule assembly and stability. Apparently involved in the establishment and maintenance of neuronal polarity. Mutations can result in several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. Nine differentially spliced isoforms have been described. The short isoforms allow plasticity of the cytoskeleton, whereas the longer isoforms may preferentially play a role in its stabilization.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21.1

Cellular Component: axon; cell soma; cytosol; dendrite; growth cone; membrane; nucleus; plasma membrane; tubulin complex

Molecular Function: actin binding; apolipoprotein binding; DNA binding; enzyme binding; Hsp90 protein binding; microtubule binding; protein binding; protein phosphatase 2A binding; receptor agonist activity; SH3 domain binding

Biological Process: astrocyte activation; axon transport of mitochondrion; caspase activation; cytoplasmic microtubule organization and biogenesis; intracellular distribution of mitochondria; memory; microglial cell activation; microtubule cytoskeleton organization and biogenesis; negative regulation of kinase activity; neurite development; positive regulation of axon extension; positive regulation of microtubule polymerization; positive regulation of superoxide release; protein oligomerization; regulation of autophagy; regulation of calcium-mediated signaling; synapse organization and biogenesis

Disease: Frontotemporal Dementia; Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-related; Parkinson Disease, Late-onset; Parkinson-dementia Syndrome; Pick Disease Of Brain; Supranuclear Palsy, Progressive, 1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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