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anti-MBTPS1 antibody :: Rabbit anti-Human, Mouse MBTPS1 Polyclonal Antibody

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Catalog # MBS7046496
Unit / Price
  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

MBTPS1, Polyclonal Antibody

Popular Item
Also Known As

MBTPS1 Antibody

Product Synonym Names
Membrane-bound transcription factor site-1 protease; Endopeptidase S1P; Subtilisin/kexin-isozyme 1; SKI-1; MBTPS1; KIAA0091; S1P; SKI1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
1052
OMIM
603355
3D Structure
ModBase 3D Structure for Q14703
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
Antigen Affinity Purified
Form/Format
Liquid
Species
Human
Immunogen
Recombinant human Membrane-bound transcription factor site-1 protease protein (C-250AA)
Conjugate
Non-conjugated
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-9785 / sc-9786 / sc-20757
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-MBTPS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MBTPS1 antibody
Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes.
Applications Tested/Suitable for anti-MBTPS1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western Blot (WB) of anti-MBTPS1 antibody
Western blot
All lanes: MBTPS1antibody at 4.06ug/ml+ Mouse kidney tissue
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 118 kDa
Observed band size: 118 kDa

anti-MBTPS1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-MBTPS1 antibody
Immunohistochemistry of paraffin-embedded human lung tissue using MBS7046496 at dilution 1:100
anti-MBTPS1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-MBTPS1 antibody
Immunohistochemistry of paraffin-embedded human small intestine using MBS7046496 at dilution 1:100
anti-MBTPS1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for MBTPS1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
117,749 Da
NCBI Official Full Name
membrane-bound transcription factor site-1 protease preproprotein
NCBI Official Synonym Full Names
membrane bound transcription factor peptidase, site 1
NCBI Official Symbol
MBTPS1  [Similar Products]
NCBI Official Synonym Symbols
S1P; PCSK8; SKI-1
  [Similar Products]
NCBI Protein Information
membrane-bound transcription factor site-1 protease
UniProt Protein Name
Membrane-bound transcription factor site-1 protease
UniProt Synonym Protein Names
Endopeptidase S1P; Subtilisin/kexin-isozyme 1; SKI-1
UniProt Gene Name
MBTPS1  [Similar Products]
UniProt Synonym Gene Names
KIAA0091; S1P; SKI1; SKI-1  [Similar Products]
UniProt Entry Name
MBTP1_HUMAN
NCBI Summary for MBTPS1
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction. [provided by RefSeq, Feb 2014]
UniProt Comments for MBTPS1
MBTPS1: Catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His- Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Belongs to the peptidase S8 family.

Protein type: Protease; EC 3.4.21.112; Endoplasmic reticulum; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16q24

Cellular Component: endoplasmic reticulum lumen; Golgi membrane

Molecular Function: serine-type endopeptidase activity

Biological Process: lysosome organization and biogenesis; membrane protein intracellular domain proteolysis; proteolysis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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