NP_001094286.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
27,245 Da
NCBI Official Full Name
mediator of RNA polymerase II transcription subunit 7
NCBI Official Synonym Full Names
mediator complex subunit 7
NCBI Protein Information
mediator of RNA polymerase II transcription subunit 7
UniProt Protein Name
Mediator of RNA polymerase II transcription subunit 7
UniProt Synonym Protein Names
Activator-recruited cofactor 34 kDa component; ARC34; Cofactor required for Sp1 transcriptional activation subunit 9; CRSP complex subunit 9; Mediator complex subunit 7; RNA polymerase transcriptional regulation mediator subunit 7 homolog; Transcriptional coactivator CRSP33
UniProt Synonym Gene Names
UniProt Entry Name
MED7_HUMAN
NCBI Summary for MED7
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for MED7
MED7: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 7 family.
Chromosomal Location of Human Ortholog: 5q33.3
Cellular Component: nucleoplasm; Srb-mediator complex; transcription factor complex; ubiquitin ligase complex
Molecular Function: protein binding; transcription coactivator activity
Biological Process: gene expression; protein ubiquitination; regulation of transcription from RNA polymerase II promoter; stem cell maintenance; transcription initiation from RNA polymerase II promoter
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Products associated with anti-MED7 antibody
Pathways associated with anti-MED7 antibody
Diseases associated with anti-MED7 antibody
Organs/Tissues associated with anti-MED7 antibody
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