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anti-STXBP1 antibody :: Goat MUNC18/STXBP1 Polyclonal Antibody

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Catalog # MBS420125
Unit / Price
  0.1 mg  /  $300 +1 FREE 8GB USB
Product Name

MUNC18/STXBP1, Polyclonal Antibody

Also Known As

Goat anti-MUNC18/STXBP1 (isoform a) Antibody

Product Synonym Names
STXBP1; MUNC18-1; UNC18; hUNC18; syntaxin binding protein 1; Hunc18; rbSec1; syntaxin-binding protein 1; RP11-56D16.3; EIEE4; FLJ37475; RBSEC1; STXBP1 antibody; MUNC18-1 antibody; UNC18 antibody; hUNC18 antibody; syntaxin binding protein 1 antibody; Hunc18 antibody; rbSec1 antibody; syntaxin-binding protein 1 antibody; RP11-56D16.3 antibody; EIEE4 antibody; FLJ37475 antibody; RBSEC1 antibody; MUNC18 / STXBP1 (isoform a)
Product Synonym Gene Name
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
Immunogen Sequence
Species Reactivity
Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
100ug specific antibody in 200ul (lot specific)
Peptide with sequence C-SRVSFEDQAPTME, from the C Terminus of the protein sequence according to NP_003156.1.
C Terminus
This antibody is expected to recognize isoform a (NP_003156.1).
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-STXBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-STXBP1 antibody
Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-STXBP1 antibody
Peptide ELISA: Antibody detection limit dilution 1: 16000.
Immunohistochemistry: In paraffin embedded Human Brain cortex shows vesicular staining in neuronal bodies. Recommended concentration, 5-10ug/ml.
Western Blot: Approx 75kDa band observed in Human and Mouse Brain lysates (calculated MW of 68.7kDa according to NP_003156.1). Recommended concentration: 0.1-0.3ug/ml.

Western Blot (WB) of anti-STXBP1 antibody
(0.1ug/ml) staining of Human Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-STXBP1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-STXBP1 antibody
(5ug/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-STXBP1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for STXBP1. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
68,736 Da
NCBI Official Full Name
syntaxin-binding protein 1 isoform a
NCBI Official Synonym Full Names
syntaxin binding protein 1
NCBI Official Symbol
STXBP1  [Similar Products]
NCBI Official Synonym Symbols
P67; NSEC1; UNC18; RBSEC1; MUNC18-1
  [Similar Products]
NCBI Protein Information
syntaxin-binding protein 1
UniProt Protein Name
Syntaxin-binding protein 1
UniProt Synonym Protein Names
MUNC18-1; N-Sec1; Protein unc-18 homolog 1; Unc18-1; Protein unc-18 homolog A; Unc-18A; p67
Protein Family
UniProt Gene Name
STXBP1  [Similar Products]
UniProt Synonym Gene Names
UNC18A; Unc18-1; Unc-18A  [Similar Products]
UniProt Entry Name
NCBI Summary for STXBP1
This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]
UniProt Comments for STXBP1
STXBP1: may participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions. Two splice-variant isoforms have been described.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 9q34.1

Cellular Component: cytoplasm; cytosol; mitochondrion; myelin sheath; nucleoplasm; plasma membrane; protein complex; terminal button

Molecular Function: identical protein binding; protein binding; protein domain specific binding; protein kinase binding; protein N-terminus binding; SNARE binding; syntaxin binding; syntaxin-1 binding

Biological Process: axon target recognition; glutamate secretion; negative regulation of neuron apoptosis; negative regulation of synaptic transmission, GABAergic; neuromuscular synaptic transmission; neurotransmitter secretion; platelet degranulation; positive regulation of calcium ion-dependent exocytosis; protein stabilization; protein transport; regulation of synaptic vesicle fusion to presynaptic membrane; synaptic vesicle maturation; vesicle docking during exocytosis

Disease: Epileptic Encephalopathy, Early Infantile, 4
Research Articles on STXBP1
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