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anti-NCOR1 antibody :: Rabbit anti-Human, Mouse NCOR1 Polyclonal Antibody

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Catalog # MBS628541
Unit / Price
  0.2 mL  /  $550 +1 FREE 8GB USB
anti-NCOR1 antibody
Product Name

NCOR1, Polyclonal Antibody

Popular Item
Also Known As

NCOR1, NT (Nuclear Receptor Co-repressor 1, N-CoR, KIAA1047)

Product Synonym Names
Anti -NCOR1, NT (Nuclear Receptor Co-repressor 1, N-CoR, KIAA1047)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 17; NC_000017.10 (15933408..16118874, complement). Location: 17p11.2
OMIM
600849
3D Structure
ModBase 3D Structure for O75376
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Specificity
Recognizes human NCOR1. Species Crossreactivity: mouse.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Immunogen
Synthetic peptide corresponding to aa24-54 from the N-terminal region of human NCOR1, conjugated to KLH.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-NCOR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NCOR1 antibody
NCOR1 mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. The gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined.
Product Categories/Family for anti-NCOR1 antibody
Applications Tested/Suitable for anti-NCOR1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-NCOR1 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100
NCBI/Uniprot data below describe general gene information for NCOR1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
270,210 Da[Similar Products]
NCBI Official Full Name
nuclear receptor corepressor 1 isoform 3
NCBI Official Synonym Full Names
nuclear receptor corepressor 1
NCBI Official Symbol
NCOR1  [Similar Products]
NCBI Official Synonym Symbols
N-CoR; TRAC1; N-CoR1; hN-CoR; KIAA1047; MGC104216
  [Similar Products]
NCBI Protein Information
nuclear receptor corepressor 1; OTTHUMP00000065575; OTTHUMP00000065577; OTTHUMP00000065578; OTTHUMP00000065580; nuclear receptor co-repressor 1; thyroid hormone- and retinoic acid receptor-associated corepressor 1
UniProt Protein Name
Nuclear receptor corepressor 1
UniProt Gene Name
NCOR1  [Similar Products]
UniProt Synonym Gene Names
KIAA1047  [Similar Products]
UniProt Entry Name
NCOR1_HUMAN
NCBI Summary for NCOR1
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.
UniProt Comments for NCOR1
N-CoR1: is a protein that regulates the activity of some transcription factors, including nuclear receptors, by promoting histone deacetylation and chromatin condensation, thereby altering the accessibility of various genes to the transcriptional machinery. Is known to play a role genetic programming including that for myogenesis. Is a component of a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid and the retinoic acid receptors in the absence of ligand. Interacts with the catalytic domain of HDAC9. Increased expression correlates with the loss of vitamin D responsiveness in aggressive androgen-independent prostate cancer cells. Its gene tends to be overexpressed in multiple-myeloma cell lines.

Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: nucleoplasm; transcription factor complex; Sin3 complex; transcriptional repressor complex; membrane; spindle microtubule; cytoplasm; histone deacetylase complex; nuclear chromatin; nucleus

Molecular Function: retinoid X receptor binding; protein binding; histone deacetylase regulator activity; sequence-specific DNA binding; histone deacetylase binding; thyroid hormone receptor binding; chromatin binding; transcription corepressor activity; transcription factor activity; nuclear hormone receptor binding

Biological Process: transcription from RNA polymerase II promoter; circadian rhythm; CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; transcription initiation from RNA polymerase II promoter; negative regulation of JNK cascade; establishment and/or maintenance of chromatin architecture; Notch signaling pathway; transcription, DNA-dependent; regulation of multicellular organism growth; thalamus development; chromatin modification; cellular lipid metabolic process; spindle assembly; negative regulation of transcription from RNA polymerase II promoter; positive regulation of histone deacetylation; cholesterol homeostasis; transforming growth factor beta receptor signaling pathway; gene expression; circadian regulation of gene expression; negative regulation of phosphoinositide 3-kinase cascade
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withanti-NCOR1 antibody
 Reference Product  PubMed Publications
  antibody  > publications with NCOR1 and
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