NP_001177367.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 270 kDa Predicted: 271 kDa
NCBI Official Full Name
nuclear receptor corepressor 1 isoform 2
NCBI Official Synonym Full Names
nuclear receptor corepressor 1
NCBI Official Synonym Symbols
N-CoR; TRAC1; N-CoR1; hN-CoR; PPP1R109 [Similar Products]
NCBI Protein Information
nuclear receptor corepressor 1
UniProt Protein Name
Nuclear receptor corepressor 1
UniProt Synonym Gene Names
NCBI Summary for NCoR1
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]
UniProt Comments for NCoR1
Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024).
Research Articles on NCoR1
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Products associated with anti-NCoR1 antibody
Pathways associated with anti-NCoR1 antibody
Diseases associated with anti-NCoR1 antibody
Organs/Tissues associated with anti-NCoR1 antibody
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