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anti-NEDD9 antibody :: Rabbit anti-Human, Mouse NEDD9 Polyclonal Antibody

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Catalog # MBS9131931
Unit / Price
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  0.05 mL  /  $200 +1 FREE 8GB USB
  0.1 mL  /  $275 +1 FREE 8GB USB
  0.2 mL  /  $430 +1 FREE 8GB USB
Western Blot (WB)
Product Name

NEDD9, Polyclonal Antibody

Popular Item
Full Product Name

NEDD9 Polyclonal Antibody

Product Synonym Names
CAS-L; CAS2; CASL; CASS2; HEF1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
L43821 mRNA
3D Structure
ModBase 3D Structure for Q14511
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
Affinity Purification
Immunogen
Recombinant protein of human NEDD9
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-NEDD9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NEDD9 antibody
The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants.
Product Categories/Family for anti-NEDD9 antibody
Applications Tested/Suitable for anti-NEDD9 antibody
Western Blot (WB)
Application Notes for anti-NEDD9 antibody
WB: 1:500 - 2000

Western Blot (WB) of anti-NEDD9 antibody
Western blot analysis of extracts of B-cell cells, using NEDD9 Antibody at 1:3000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 10s.
anti-NEDD9 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for NEDD9. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
93kDa
NCBI Official Full Name
Enhancer of filamentation 1
NCBI Official Synonym Full Names
neural precursor cell expressed, developmentally down-regulated 9
NCBI Official Symbol
NEDD9  [Similar Products]
NCBI Official Synonym Symbols
CAS2; CASL; HEF1; CAS-L; CASS2
  [Similar Products]
NCBI Protein Information
enhancer of filamentation 1
UniProt Protein Name
Enhancer of filamentation 1
UniProt Synonym Protein Names
CRK-associated substrate-related protein; CAS-L; CasL
Protein Family
UniProt Gene Name
NEDD9  [Similar Products]
UniProt Synonym Gene Names
CASL; CASS2; hEF1; CAS-L; CasL; NEDD-9  [Similar Products]
NCBI Summary for NEDD9
The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
UniProt Comments for NEDD9
Cas-L: a widely expressed docking protein which plays a central coordinating role for tyrosine-kinase-based signaling in cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form. Phosphorylated following integrin beta-1, antigen receptor, or C1a calcitonin receptor signaling. Transformation of fibroblasts with v-ABL results in an increase in its tyrosine phosphorylation. Phosphorylated by focal adhesion kinase. Highly expressed in kidney, lung, and placenta. Also detected in T-cells, B-cells and diverse cell lines.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 6p24.2

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; plasma membrane; spindle

Molecular Function: protein binding

Biological Process: signal transduction
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-NEDD9 antibody
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