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anti-DCC antibody :: anti-Mouse, Human Netrin receptor DCC Polyclonal Antibody

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Catalog # MBS857291
Unit / Price
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  0.1 mL  /  $290 +1 FREE 8GB USB
Testing Data
Product Name

Netrin receptor DCC, Polyclonal Antibody

Full Product Name

Netrin receptor DCC Antibody

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
120470
3D Structure
ModBase 3D Structure for P43146
Clonality
Polyclonal
Isotype
IgG
Species Reactivity
Mouse, Human
Specificity
This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to AIRE.
Purity/Purification
Affinity Purified
Form/Format
Liquid
Cellular Localization
Cell Membrane
Positive Control
Human brain, mouse brain
Preparation and Storage
Store at +4 degree C after thawing. Aliquot store at-20 degree C or-80 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-DCC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DCC antibody
Netrin receptor DCC (deleted colorectal careinoma) was originally identified as a putative tumor suppressor gene that is lost in more than 70% of colorectal cancers. The DCC protein is a type I transmembrane glycoprotein that belongs to the immunoglobulin (Ig) superfamily. It is found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Native DCC is found in three isoforms. Two forms, a long and a short isoform, are produced from the same gene but have different initiation sites. The third isoform, produced by alternative splicing, is expressed only in embryonic tissue. Colorectal tumors that lost their capacity to differentiate into mucus producing cells uniformly lack DCC expression. Inactivation of DCC due to allelic deletion or point mutations may cause both lymphatic and hematogenous metastasis of esophageal squamous cell carcinomas.
Application Notes for anti-DCC antibody
WB: 1:500-1:1,000

Testing Data of anti-DCC antibody
Western blot analysis on Hela using anti- Netrin receptor DCC polyclonal antibody
anti-DCC antibody Testing Data image
NCBI/Uniprot data below describe general gene information for DCC. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
NCBI Official Full Name
netrin receptor DCC
NCBI Official Synonym Full Names
DCC netrin 1 receptor
NCBI Official Symbol
NCBI Official Synonym Symbols
CRC18; CRCR1; MRMV1; HGPPS2; IGDCC1; NTN1R1
  [Similar Products]
NCBI Protein Information
netrin receptor DCC
UniProt Protein Name
Netrin receptor DCC
UniProt Synonym Protein Names
Colorectal cancer suppressor; Immunoglobulin superfamily DCC subclass member 1; Tumor suppressor protein DCC
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
IGDCC1  [Similar Products]
NCBI Summary for DCC
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]
UniProt Comments for DCC
Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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