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anti-NCS1 antibody :: Rabbit anti-Human, Mouse Neuronal calcium sensor 1 Polyclonal Antibody

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Catalog # MBS1493938
Unit / Price
  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

Neuronal calcium sensor 1 (NCS1), Polyclonal Antibody

Popular Item
Also Known As

Rabbit anti-human Neuronal calcium sensor 1 polyclonal Antibody(NCS1)

Product Synonym Names
NCS-1; Frequenin homolog; Frequenin-like protein; Frequenin-like ubiquitous protein; NCS1; FLUP; FREQ
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
172
OMIM
603315
3D Structure
ModBase 3D Structure for P62166
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Neuronal calcium sensor 1 protein (1-190aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-13165 / sc-13167 / sc-13166 / sc-13037
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-NCS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NCS1 antibody
Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel.
Applications Tested/Suitable for anti-NCS1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-NCS1 antibody
Recommended dilution: WB:1:500-1:2000
IHC:1:20-1:200

Western Blot (WB) of anti-NCS1 antibody
All lanes: Neuronal calcium sensor 1 antibody at 10ug/ml
Lane 1:Hela whole cell lysate
Lane 2:rat kidney tissue
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 22,20 kDa
Observed band size: 22 kDa

anti-NCS1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-NCS1 antibody
Immunohistochemistry of paraffin-embedded human breast cancer using MBS1493938 at dilution 1:100
anti-NCS1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for NCS1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
19,728 Da
NCBI Official Full Name
neuronal calcium sensor 1 isoform 2
NCBI Official Synonym Full Names
neuronal calcium sensor 1
NCBI Official Symbol
NCBI Official Synonym Symbols
FLUP; FREQ
  [Similar Products]
NCBI Protein Information
neuronal calcium sensor 1
UniProt Protein Name
Neuronal calcium sensor 1
UniProt Synonym Protein Names
Frequenin homolog; Frequenin-like protein; Frequenin-like ubiquitous protein
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
FLUP; FREQ; NCS-1  [Similar Products]
UniProt Entry Name
NCS1_HUMAN
NCBI Summary for NCS1
This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for NCS1
FREQ: Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N- type voltage-gated calcium channel. Interacts with KCND2. Interacts in a calcium-independent manner with PI4KB. This binding competes with CALN2/CABP7 binding to PI4KB. Interacts with ARF1, ARF3, ARF5 and ARF6. Interacts in a calcium-dependent manner with PICK1 (via AH domain). Interacts with IL1RAPL1. Belongs to the recoverin family.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: axon; cell junction; cytoplasm; cytosol; dendrite; Golgi apparatus; intracellular membrane-bound organelle; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; postsynaptic membrane

Molecular Function: calcium ion binding; magnesium ion binding; protein binding; protein kinase binding; voltage-gated calcium channel activity

Biological Process: phosphoinositide-mediated signaling; positive regulation of exocytosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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