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anti-TACR3 antibody :: Rabbit anti-Human, Mouse NK3R Polyclonal Antibody

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Catalog # MBS150256
Unit / Price
  0.1 mg  /  $375 +1 FREE 8GB USB
Product Name

NK3R (TACR3), Polyclonal Antibody

Full Product Name

NK3R Antibody

Product Synonym Names
NK3R; NKR; HH11; NK3R; NK-3R; TAC3RL; TAC3R; Neuromedin-K receptor; NK-3 receptor; NKR; tachykinin receptor 3
Antibody/Peptide Pairs
NK3R peptide (MBS151959) is used for blocking the activity of NK3R antibody (MBS150256)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
gene 614840
3D Structure
ModBase 3D Structure for P29371
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
NK3R Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (lot specific)
Conjugate
Unconjugated
Immunogen
NK3R antibody was raised against a 18 amino acid synthetic peptide from near the center of human NK3R.
Buffer
NK3R Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
NK3R antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Other Notes
Small volumes of anti-TACR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TACR3 antibody
NK3R Antibody: The tachykinins are a family of small peptides that include the neurotransmitters substance P, neurokinin A, and neurokinin B, which can act on three related but distinct seven transmembrane G-proteins coupled receptors, albeit at different concentrations. The NK-3 receptor (NK3R) has greatest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following binding of its ligand, NK3R activates a phosphatidylinositol-calcium second messenger system. It is likely these signals lead to the release of vasopressin and oxytocin into the circulation. NK3R may be involved in learning and memory as mice lacking this gene expressed cognitive deficits compared to normal mice. Although it has been suggested that NK3R plays a role in the regulation of vagal afferent relay neurons, it is likely that these receptors are activated by substance P or neurokinin A, as the airway nerves do not express neurokinin B. NK3R antibody does not recognize NK1R or NK2R.
Applications Tested/Suitable for anti-TACR3 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-TACR3 antibody
NK3R antibody can be used for detection of NK3R by Western blot at 0.5 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-TACR3 antibody
Western blot analysis of NK3R in RAW264.7 cell lysate with NK3R antibody at (A) 0.5 and (B) 2 μg/mL.
anti-TACR3 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-TACR3 antibody
Immunohistochemistry of NK3R in human brain tissue with NK3R antibody at 5 μg/mL.
anti-TACR3 antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-TACR3 antibody
Immunofluorescence of NK3R in Human Brain cells with NK3R antibody at 20 μg/mL.
anti-TACR3 antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for TACR3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
52,202 Da
NCBI Official Full Name
Neuromedin-K receptor
NCBI Official Synonym Full Names
tachykinin receptor 3
NCBI Official Symbol
TACR3  [Similar Products]
NCBI Official Synonym Symbols
NKR; HH11; NK3R; NK-3R; TAC3RL
  [Similar Products]
NCBI Protein Information
neuromedin-K receptor; NK-3 receptor; neurokinin B receptor; neurokinin beta receptor
UniProt Protein Name
Neuromedin-K receptor
UniProt Synonym Protein Names
NK-3 receptor; NK-3R; Neurokinin B receptor; Tachykinin receptor 3
Protein Family
UniProt Gene Name
TACR3  [Similar Products]
UniProt Synonym Gene Names
NK3R; TAC3R; NKR; NK-3R  [Similar Products]
UniProt Entry Name
NK3R_HUMAN
NCBI Summary for TACR3
This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Jul 2008]
UniProt Comments for TACR3
TACR3: This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 4q25

Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; nucleus

Molecular Function: protein binding; tachykinin receptor activity

Biological Process: tachykinin signaling pathway; hyperosmotic salinity response; regulation of dopamine metabolic process; response to morphine; positive regulation of heart rate; response to cocaine; positive regulation of blood pressure; response to estradiol stimulus; aging

Disease: Hypogonadotropic Hypogonadism 11 With Or Without Anosmia
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-TACR3 antibody
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >1 publications with TACR3 and Muscle
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