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anti-NME2 antibody :: Rabbit anti-Human, Mouse NME2 Polyclonal Antibody

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Catalog # MBS9407020
Unit / Price
  0.1 mL  /  $255 +1 FREE 8GB USB
Product Name

NME2, Polyclonal Antibody

Popular Item
Also Known As

NME2 Antibody

Product Synonym Names
PUF; NDKB; NDPKB; NM23B; NDPK-B; NM23-H2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
267
OMIM
156491
3D Structure
ModBase 3D Structure for P22392
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Specificity
The antibody detects endogenous levels of total NME2 protein.
Purity/Purification
Antigen affinity purification.
Form/Format
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Concentration
2.8 mg/ml (lot specific)
Immunogen Type
Peptide
Immunogen Description
Synthetic peptide corresponding to residues near the C terminal of human NME/NM23 nucleoside diphosphate kinase 2
Target Name
NME2
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-NME2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NME2 antibody
Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product.
Product Categories/Family for anti-NME2 antibody
Applications Tested/Suitable for anti-NME2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-NME2 antibody
Western blotting: 1:1000-1:5000
Immunohistochemistry: 1:30-1:150

Testing Data of anti-NME2 antibody
Gel: 12%SDS-PAGE Lysates (from left to right): Hela, NIH/3T3, lncap and 293T cell, mouse brain tissue, A549 and Jurkat cell Amount of lysate: 40ug per lane Primary antibody: 1/300 dilution Secondary antibody dilution: 1/8000Exposure time: 30 seconds
anti-NME2 antibody Testing Data image
Immunohistochemistry (IHC) of anti-NME2 antibody
Immunohistochemical analysis of paraffin-embedded Human prostate cancer tissue using at dilution 1/40.
anti-NME2 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for NME2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
Molecular Weight
17kDa
NCBI Official Full Name
NME1-NME2 protein
NCBI Official Synonym Full Names
NME1-NME2 readthrough
NCBI Official Symbol
NME1-NME2  [Similar Products]
NCBI Official Synonym Symbols
NMELV; NM23-LV
  [Similar Products]
NCBI Protein Information
NME1-NME2 protein
UniProt Protein Name
Nucleoside diphosphate kinase B
UniProt Synonym Protein Names
C-myc purine-binding transcription factor PUF; Histidine protein kinase NDKB (EC:2.7.13.3); nm23-H2
UniProt Gene Name
UniProt Synonym Gene Names
NM23B; NDK B; NDP kinase B  [Similar Products]
UniProt Entry Name
NDKB_HUMAN
NCBI Summary for NME2
This locus represents naturally occurring read-through transcription between the neighboring NME1 and NME2 genes. The significance of this read-through transcription and the function of the resulting protein product have not yet been determined. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2010]
UniProt Comments for NME2
NME2: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity. Belongs to the NDK family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleotide Metabolism - purine; Kinase, other; Nucleotide Metabolism - pyrimidine; Nuclear receptor co-regulator; EC 2.7.13.3; EC 2.7.4.6; Kinase, nucleoside diphosphate; Other group; NDK family

Chromosomal Location of Human Ortholog: 17q21.3

Cellular Component: ruffle; centrosome; focal adhesion; mitochondrion; membrane; lamellipodium; perinuclear region of cytoplasm; cytoplasm; intermediate filament; nucleus; cytosol

Molecular Function: protein binding; gamma-tubulin binding; metal ion binding; protein histidine kinase activity; intermediate filament binding; nucleoside diphosphate kinase activity; protein kinase binding; transcription factor activity; ATP binding; single-stranded DNA binding

Biological Process: integrin-mediated signaling pathway; GTP biosynthetic process; peptidyl-histidine phosphorylation; response to cAMP; transcription, DNA-dependent; nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside and nucleotide metabolic process; UTP biosynthetic process; negative regulation of myeloid leukocyte differentiation; hippocampus development; nucleoside diphosphate phosphorylation; response to testosterone stimulus; CTP biosynthetic process; regulation of transcription, DNA-dependent; pyrimidine nucleotide metabolic process; nucleoside triphosphate biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; cell adhesion; regulation of epidermis development; positive regulation of epithelial cell proliferation; positive regulation of keratinocyte differentiation; purine nucleotide metabolic process; negative regulation of apoptosis; response to amine stimulus
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withanti-NME2 antibody
 Reference Product  PubMed Publications
 NME1 antibody  >2 publications with NME2 and NME1
Organs/Tissues associated with anti-NME2 antibody
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1 publications with NME2 and Lung
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