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anti-OAS2 antibody :: Rabbit anti-Human, Mouse OAS2 Polyclonal Antibody

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Catalog # MBS9402391
Unit / Price
  0.1 mL  /  $255 +1 FREE 8GB USB
Testing Data
Product Name

OAS2, Polyclonal Antibody

Popular Item
Also Known As

OAS2 Antibody

Product Synonym Names
MGC78578; p69 OAS / p71 OAS; p69OAS / p71OAS
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
172
OMIM
603350
3D Structure
ModBase 3D Structure for P29728
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Specificity
The antibody detects endogenous levels of total OAS2 protein.
Purity/Purification
Antigen affinity purification.
Form/Format
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Concentration
0.6 mg/ml (lot specific)
Immunogen Type
Recombinant Protein
Immunogen Description
Fusion protein corresponding to a region derived from internal residues of human 2'-5'-oligoadenylate synthetase 2, 69/71kDa
Target Name
OAS2
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-OAS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-OAS2 antibody
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.
Product Categories/Family for anti-OAS2 antibody
Applications Tested/Suitable for anti-OAS2 antibody
Western Blot (WB)
Application Notes for anti-OAS2 antibody
Western blotting: 1:200-1:1000

Testing Data of anti-OAS2 antibody
Gel: 10%SDS-PAGE Lysates (from left to right): Mouse heart tissue Amount of lysate: 40ug per lane Primary antibody: 1/300 dilution Secondary antibody dilution: 1/8000 Exposure time: 10 seconds
anti-OAS2 antibody Testing Data image
NCBI/Uniprot data below describe general gene information for OAS2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
19,517 Da
NCBI Official Full Name
2'-5'-oligoadenylate synthase 2 isoform 3
NCBI Official Synonym Full Names
2'-5'-oligoadenylate synthetase 2, 69/71kDa
NCBI Official Symbol
NCBI Protein Information
2'-5'-oligoadenylate synthase 2
UniProt Protein Name
2'-5'-oligoadenylate synthase 2
UniProt Synonym Protein Names
p69 OAS / p71 OAS; p69OAS / p71OAS
UniProt Gene Name
UniProt Synonym Gene Names
(2-5')oligo(A) synthase 2; 2-5A synthase 2; p69OAS / p71OAS  [Similar Products]
UniProt Entry Name
OAS2_HUMAN
NCBI Summary for OAS2
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for OAS2
OAS2: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Belongs to the 2-5A synthase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.7.84; Transferase

Chromosomal Location of Human Ortholog: 12q24.2

Cellular Component: membrane; mitochondrion; intracellular membrane-bound organelle; endoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm; cytosol; nucleus

Molecular Function: zinc ion binding; metal ion binding; double-stranded RNA binding; ATP binding; 2'-5'-oligoadenylate synthetase activity

Biological Process: response to virus; cytokine and chemokine mediated signaling pathway; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; RNA catabolic process; protein myristoylation; protein amino acid glycosylation; purine nucleotide biosynthetic process; defense response to virus
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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